Crystal structure and molecular docking studies of 1,2,4,5-tetraaryl substituted imidazoles

2-(4-Bromophenyl)-1-(3-chloro-2-methylphenyl)- 4,5-diphenyl-1 -imidazole ( ) and 1-(3-chloro-2-methylphenyl)-2-(4-chlorophenyl)-4,5-diphenyl-1 -imidazole ( ) were synthesized by one-pot four-component reactions. These compounds crystallize in the monoclinic crystal system with the space group . The...

Full description

Saved in:
Bibliographic Details
Published in:Heterocyclic communications 2018-08, Vol.24 (4), p.205-210
Main Authors: Sharma, Devinder Kumar, Jayashree, Avvadukkam, Narayana, Badiadka, Sarojini, Balladka Kunhana, Ravikumar, Chandrasekaran, Murugavel, Saminathan, Anthal, Sumati, Kant, Rajni
Format: Article
Language:English
Subjects:
Chemical synthesis
Crystal structure
Imidazole
Molecular docking
Molecular structure
multi-component
Proteins
single crystal
X-ray diffraction
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:2-(4-Bromophenyl)-1-(3-chloro-2-methylphenyl)- 4,5-diphenyl-1 -imidazole ( ) and 1-(3-chloro-2-methylphenyl)-2-(4-chlorophenyl)-4,5-diphenyl-1 -imidazole ( ) were synthesized by one-pot four-component reactions. These compounds crystallize in the monoclinic crystal system with the space group . The crystal structures were solved by direct methods and refined by a full matrix least squares procedure to a final R value of 0.0572 ( ) and 0.0588 ( ) for 2748 and 2278 observed reflections, respectively. Molecular docking studies were implemented to understand the inhibitory activity of related compounds against glucosamine 6-phosphate (GlcN-6-P) synthase, the target protein for the antimicrobial agents.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2017-0165