A highly sensitive sensor of paracetamol based on zinc-layered hydroxide-L-phenylalanate-modified multiwalled carbon nanotube paste electrode

A new zinc-layered hydroxide- L -phenylalanate (ZLH-LP)-modified multiwalled carbon nanotube (MWCNT) was prepared as a new material of paste electrode for the detection of paracetamol (PCM) in 1.0 × 10 −1  M phosphate buffer solution and at pH 7.5. The electrochemical characterization of the MWCNTs/...

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Bibliographic Details
Published in:Journal of solid state electrochemistry 2018-09, Vol.22 (9), p.2691-2701
Main Authors: Ahmad, Mohamad Syahrizal, Isa, Illyas Md, Hashim, Norhayati, Si, Suyanta M., Saidin, Mohamad Idris
Format: Article
Language:English
Subjects:
Analgesics
Analytical Chemistry
Buffer solutions
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Correlation coefficients
Electrochemical analysis
Electrochemical impedance spectroscopy
Electrochemistry
Electrodes
Energy Storage
Morphology
Multi wall carbon nanotubes
Nanotubes
Original Paper
Oxidation
Physical Chemistry
Reproducibility
Scanning electron microscopy
Square waves
Transmission electron microscopy
Voltammetry
Zinc
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Summary:A new zinc-layered hydroxide- L -phenylalanate (ZLH-LP)-modified multiwalled carbon nanotube (MWCNT) was prepared as a new material of paste electrode for the detection of paracetamol (PCM) in 1.0 × 10 −1  M phosphate buffer solution and at pH 7.5. The electrochemical characterization of the MWCNTs/ZLH-LP paste electrode was characterized by square wave voltammetry, electrochemical impedance spectroscopy, and cyclic voltammetry while the morphology properties of the MWCNTs, ZLH-LP, and MWCNTs/ZLH-LP were investigated using transmission electron microscopy and scanning electron microscopy. Under optimized conditions, the MWCNTs/ZLH-LP paste electrode demonstrated an excellent electrocatalytic activity towards oxidation of PCM in the linear responses’ ranges from 7.0 × 10 −7  M to 1.0 × 10 −4  M (correlation coefficient, 0.996) with the limit of detection obtained at 8.3 × 10 −8  M. As a conclusion, the MWCNTs/ZLH-LP paste electrode revealed good repeatability, reproducibility, and stability, and was found to be applicable for use in pharmaceutical tablet samples. Graphical abstract ᅟ
ISSN:1432-8488
1433-0768
DOI:10.1007/s10008-018-3979-y