Biological potential of oxo-vanadium salicylediene amino-acid complexes as cytotoxic, antimicrobial, antioxidant and DNA interaction

• Published in: Journal of photochemistry and photobiology. B, Biology Biology, 2018-07, Vol.184, p.34-43
• Main Authors: Adam, Mohamed Shaker S., Elsawy, Hany
• Format: Article
• Language: English
• Subjects: Alanine; Amino acids; Amino Acids - chemistry; Amino Acids - pharmacology; Amino Acids - toxicity; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Anti-Infective Agents - toxicity; Antibacterial; Antifungal; Antifungal activity; Antineoplastic drugs; Antioxidant; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Antioxidants - toxicity; Antitumor agents; Bacteria - drug effects; Biological activity; Cell Proliferation - drug effects; Chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Coordination Complexes - toxicity; Cytotoxicity; Deoxyribonucleic acid; DFT calculations; DNA; DNA - chemistry; Drug resistance; Electrophoresis; Fungi - drug effects; Fungicides; Gel electrophoresis; Glycine; Imines; Interaction parameters; Leucine; Magnetic measurement; Mass spectra; Microbial Sensitivity Tests; Oxo-vanadium; Pyridines; Quantum Theory; Reagents; Salicylic Acid - chemistry; Salicylic Acid - pharmacology; Salicylic Acid - toxicity; Schiff base; Schiff Bases - chemistry; Sodium; Spectrophotometry; Strong interactions (field theory); Toxicity; Tryptophan; Vanadium; Vanadium - chemistry; Vanadium - pharmacology; Vanadium - toxicity
• ISSN: 1011-1344; 1873-2682
• DOI: 10.1016/j.jphotobiol.2018.05.002

New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes are synthesized and characterized. They are synthesized from the reaction of sodium salicylaldehyde-5-sulfonate, some amino acids, alanine (VOHL1), leucine (VOHL2) or glycine (VOHL3) in an aqueous media, and leucine (VOHLpy1) or tryptophan (VOHLpy2) in pyridine with vanadyl acetylacetonate. The complexes are characterized by EA, TGA, IR, UV–Visible and mass spectra, conductivity and magnetic measurements. The biological activity of the VO-complexes shows that VOHL1, VOHL2 and VOHL3 exhibit anti-proliferative effect and may be used as anticancer drugs. VO-complexes manifest high toxicity, except VOHL2 is less toxic, and could be applied for the human being. VOHL1, VOHL2 and VOHL3 display remarkable SOD like potential and act as high inhibiting reagents. VOHLpy1 and VOHLpy2 show low inhibiting potentials. VO-complexes have good anti-oxidant effect, in which VOHL3 affords the best antioxidant activity. The interaction between VO-complexes and DNA is studied spectrophotometrically and by gel electrophoresis. Binding constants and spectrophotometric parameters indicate a strong interaction between VO-complexes and DNA. VO-complexes have respectable anti–bacterial and antifungal activities, where VOHL3 shows the maximum potential. DFT calculations of VOHL1 and VOHL3 were discussed in the light of their biological activity, which are convenient with the obtained results. [Display omitted] •New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes were synthesized and characterized.•They have high anti-proliferative effect and may be used as anticancer drugs.•They display a remarkable SOD like potential and act as high inhibiting reagents. They have also high potential as antioxidant, antibacterial and antifungal reagents.•Strong interaction between VO-complexes and DNA was detected spectrophotometrically and by gel electrophoresis.•Theoretical results (DFT calculations) are in good agreement with the experimental data.