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Biological potential of oxo-vanadium salicylediene amino-acid complexes as cytotoxic, antimicrobial, antioxidant and DNA interaction

New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes are synthesized and characterized. They are synthesized from the reaction of sodium salicylaldehyde-5-sulfonate, some amino acids, alanine (VOHL1), leucine (VOHL2) or glycine (VOHL3) in an aqueous media, and leucine (VOHLpy1)...

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Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2018-07, Vol.184, p.34-43
Main Authors: Adam, Mohamed Shaker S., Elsawy, Hany
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description New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes are synthesized and characterized. They are synthesized from the reaction of sodium salicylaldehyde-5-sulfonate, some amino acids, alanine (VOHL1), leucine (VOHL2) or glycine (VOHL3) in an aqueous media, and leucine (VOHLpy1) or tryptophan (VOHLpy2) in pyridine with vanadyl acetylacetonate. The complexes are characterized by EA, TGA, IR, UV–Visible and mass spectra, conductivity and magnetic measurements. The biological activity of the VO-complexes shows that VOHL1, VOHL2 and VOHL3 exhibit anti-proliferative effect and may be used as anticancer drugs. VO-complexes manifest high toxicity, except VOHL2 is less toxic, and could be applied for the human being. VOHL1, VOHL2 and VOHL3 display remarkable SOD like potential and act as high inhibiting reagents. VOHLpy1 and VOHLpy2 show low inhibiting potentials. VO-complexes have good anti-oxidant effect, in which VOHL3 affords the best antioxidant activity. The interaction between VO-complexes and DNA is studied spectrophotometrically and by gel electrophoresis. Binding constants and spectrophotometric parameters indicate a strong interaction between VO-complexes and DNA. VO-complexes have respectable anti–bacterial and antifungal activities, where VOHL3 shows the maximum potential. DFT calculations of VOHL1 and VOHL3 were discussed in the light of their biological activity, which are convenient with the obtained results. [Display omitted] •New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes were synthesized and characterized.•They have high anti-proliferative effect and may be used as anticancer drugs.•They display a remarkable SOD like potential and act as high inhibiting reagents. They have also high potential as antioxidant, antibacterial and antifungal reagents.•Strong interaction between VO-complexes and DNA was detected spectrophotometrically and by gel electrophoresis.•Theoretical results (DFT calculations) are in good agreement with the experimental data.
doi_str_mv 10.1016/j.jphotobiol.2018.05.002
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They are synthesized from the reaction of sodium salicylaldehyde-5-sulfonate, some amino acids, alanine (VOHL1), leucine (VOHL2) or glycine (VOHL3) in an aqueous media, and leucine (VOHLpy1) or tryptophan (VOHLpy2) in pyridine with vanadyl acetylacetonate. The complexes are characterized by EA, TGA, IR, UV–Visible and mass spectra, conductivity and magnetic measurements. The biological activity of the VO-complexes shows that VOHL1, VOHL2 and VOHL3 exhibit anti-proliferative effect and may be used as anticancer drugs. VO-complexes manifest high toxicity, except VOHL2 is less toxic, and could be applied for the human being. VOHL1, VOHL2 and VOHL3 display remarkable SOD like potential and act as high inhibiting reagents. VOHLpy1 and VOHLpy2 show low inhibiting potentials. VO-complexes have good anti-oxidant effect, in which VOHL3 affords the best antioxidant activity. The interaction between VO-complexes and DNA is studied spectrophotometrically and by gel electrophoresis. Binding constants and spectrophotometric parameters indicate a strong interaction between VO-complexes and DNA. VO-complexes have respectable anti–bacterial and antifungal activities, where VOHL3 shows the maximum potential. DFT calculations of VOHL1 and VOHL3 were discussed in the light of their biological activity, which are convenient with the obtained results. [Display omitted] •New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes were synthesized and characterized.•They have high anti-proliferative effect and may be used as anticancer drugs.•They display a remarkable SOD like potential and act as high inhibiting reagents. They have also high potential as antioxidant, antibacterial and antifungal reagents.•Strong interaction between VO-complexes and DNA was detected spectrophotometrically and by gel electrophoresis.•Theoretical results (DFT calculations) are in good agreement with the experimental data.</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/j.jphotobiol.2018.05.002</identifier><identifier>PMID: 29778887</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Alanine ; Amino acids ; Amino Acids - chemistry ; Amino Acids - pharmacology ; Amino Acids - toxicity ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Anti-Infective Agents - toxicity ; Antibacterial ; Antifungal ; Antifungal activity ; Antineoplastic drugs ; Antioxidant ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Antioxidants - toxicity ; Antitumor agents ; Bacteria - drug effects ; Biological activity ; Cell Proliferation - drug effects ; Chemical synthesis ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Coordination Complexes - toxicity ; Cytotoxicity ; Deoxyribonucleic acid ; DFT calculations ; DNA ; DNA - chemistry ; Drug resistance ; Electrophoresis ; Fungi - drug effects ; Fungicides ; Gel electrophoresis ; Glycine ; Imines ; Interaction parameters ; Leucine ; Magnetic measurement ; Mass spectra ; Microbial Sensitivity Tests ; Oxo-vanadium ; Pyridines ; Quantum Theory ; Reagents ; Salicylic Acid - chemistry ; Salicylic Acid - pharmacology ; Salicylic Acid - toxicity ; Schiff base ; Schiff Bases - chemistry ; Sodium ; Spectrophotometry ; Strong interactions (field theory) ; Toxicity ; Tryptophan ; Vanadium ; Vanadium - chemistry ; Vanadium - pharmacology ; Vanadium - toxicity</subject><ispartof>Journal of photochemistry and photobiology. 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All rights reserved.</rights><rights>Copyright Elsevier BV Jul 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-b7390e0d681cf542495d7da31919b97cbb86200d9a4afbcb2889c09e26fc3e33</citedby><cites>FETCH-LOGICAL-c402t-b7390e0d681cf542495d7da31919b97cbb86200d9a4afbcb2889c09e26fc3e33</cites><orcidid>0000-0001-8826-3558</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29778887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adam, Mohamed Shaker S.</creatorcontrib><creatorcontrib>Elsawy, Hany</creatorcontrib><title>Biological potential of oxo-vanadium salicylediene amino-acid complexes as cytotoxic, antimicrobial, antioxidant and DNA interaction</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes are synthesized and characterized. They are synthesized from the reaction of sodium salicylaldehyde-5-sulfonate, some amino acids, alanine (VOHL1), leucine (VOHL2) or glycine (VOHL3) in an aqueous media, and leucine (VOHLpy1) or tryptophan (VOHLpy2) in pyridine with vanadyl acetylacetonate. The complexes are characterized by EA, TGA, IR, UV–Visible and mass spectra, conductivity and magnetic measurements. The biological activity of the VO-complexes shows that VOHL1, VOHL2 and VOHL3 exhibit anti-proliferative effect and may be used as anticancer drugs. VO-complexes manifest high toxicity, except VOHL2 is less toxic, and could be applied for the human being. VOHL1, VOHL2 and VOHL3 display remarkable SOD like potential and act as high inhibiting reagents. VOHLpy1 and VOHLpy2 show low inhibiting potentials. VO-complexes have good anti-oxidant effect, in which VOHL3 affords the best antioxidant activity. The interaction between VO-complexes and DNA is studied spectrophotometrically and by gel electrophoresis. Binding constants and spectrophotometric parameters indicate a strong interaction between VO-complexes and DNA. VO-complexes have respectable anti–bacterial and antifungal activities, where VOHL3 shows the maximum potential. DFT calculations of VOHL1 and VOHL3 were discussed in the light of their biological activity, which are convenient with the obtained results. [Display omitted] •New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes were synthesized and characterized.•They have high anti-proliferative effect and may be used as anticancer drugs.•They display a remarkable SOD like potential and act as high inhibiting reagents. 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Elsawy, Hany</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-b7390e0d681cf542495d7da31919b97cbb86200d9a4afbcb2889c09e26fc3e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alanine</topic><topic>Amino acids</topic><topic>Amino Acids - chemistry</topic><topic>Amino Acids - pharmacology</topic><topic>Amino Acids - toxicity</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents - toxicity</topic><topic>Antibacterial</topic><topic>Antifungal</topic><topic>Antifungal activity</topic><topic>Antineoplastic drugs</topic><topic>Antioxidant</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - toxicity</topic><topic>Antitumor agents</topic><topic>Bacteria - drug effects</topic><topic>Biological activity</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Coordination Complexes - toxicity</topic><topic>Cytotoxicity</topic><topic>Deoxyribonucleic acid</topic><topic>DFT calculations</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>Drug resistance</topic><topic>Electrophoresis</topic><topic>Fungi - drug effects</topic><topic>Fungicides</topic><topic>Gel electrophoresis</topic><topic>Glycine</topic><topic>Imines</topic><topic>Interaction parameters</topic><topic>Leucine</topic><topic>Magnetic measurement</topic><topic>Mass spectra</topic><topic>Microbial Sensitivity Tests</topic><topic>Oxo-vanadium</topic><topic>Pyridines</topic><topic>Quantum Theory</topic><topic>Reagents</topic><topic>Salicylic Acid - chemistry</topic><topic>Salicylic Acid - pharmacology</topic><topic>Salicylic Acid - toxicity</topic><topic>Schiff base</topic><topic>Schiff Bases - chemistry</topic><topic>Sodium</topic><topic>Spectrophotometry</topic><topic>Strong interactions (field theory)</topic><topic>Toxicity</topic><topic>Tryptophan</topic><topic>Vanadium</topic><topic>Vanadium - chemistry</topic><topic>Vanadium - pharmacology</topic><topic>Vanadium - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adam, Mohamed Shaker S.</creatorcontrib><creatorcontrib>Elsawy, Hany</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; 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B, Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adam, Mohamed Shaker S.</au><au>Elsawy, Hany</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological potential of oxo-vanadium salicylediene amino-acid complexes as cytotoxic, antimicrobial, antioxidant and DNA interaction</atitle><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>2018-07</date><risdate>2018</risdate><volume>184</volume><spage>34</spage><epage>43</epage><pages>34-43</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><abstract>New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes are synthesized and characterized. They are synthesized from the reaction of sodium salicylaldehyde-5-sulfonate, some amino acids, alanine (VOHL1), leucine (VOHL2) or glycine (VOHL3) in an aqueous media, and leucine (VOHLpy1) or tryptophan (VOHLpy2) in pyridine with vanadyl acetylacetonate. The complexes are characterized by EA, TGA, IR, UV–Visible and mass spectra, conductivity and magnetic measurements. The biological activity of the VO-complexes shows that VOHL1, VOHL2 and VOHL3 exhibit anti-proliferative effect and may be used as anticancer drugs. VO-complexes manifest high toxicity, except VOHL2 is less toxic, and could be applied for the human being. VOHL1, VOHL2 and VOHL3 display remarkable SOD like potential and act as high inhibiting reagents. VOHLpy1 and VOHLpy2 show low inhibiting potentials. VO-complexes have good anti-oxidant effect, in which VOHL3 affords the best antioxidant activity. The interaction between VO-complexes and DNA is studied spectrophotometrically and by gel electrophoresis. Binding constants and spectrophotometric parameters indicate a strong interaction between VO-complexes and DNA. VO-complexes have respectable anti–bacterial and antifungal activities, where VOHL3 shows the maximum potential. DFT calculations of VOHL1 and VOHL3 were discussed in the light of their biological activity, which are convenient with the obtained results. [Display omitted] •New series of oxo-vanadium N-salicyledieneamino acid Schiff base complexes were synthesized and characterized.•They have high anti-proliferative effect and may be used as anticancer drugs.•They display a remarkable SOD like potential and act as high inhibiting reagents. They have also high potential as antioxidant, antibacterial and antifungal reagents.•Strong interaction between VO-complexes and DNA was detected spectrophotometrically and by gel electrophoresis.•Theoretical results (DFT calculations) are in good agreement with the experimental data.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>29778887</pmid><doi>10.1016/j.jphotobiol.2018.05.002</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8826-3558</orcidid></addata></record>
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ispartof Journal of photochemistry and photobiology. B, Biology, 2018-07, Vol.184, p.34-43
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subjects Alanine
Amino acids
Amino Acids - chemistry
Amino Acids - pharmacology
Amino Acids - toxicity
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Anti-Infective Agents - toxicity
Antibacterial
Antifungal
Antifungal activity
Antineoplastic drugs
Antioxidant
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Antioxidants - toxicity
Antitumor agents
Bacteria - drug effects
Biological activity
Cell Proliferation - drug effects
Chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Coordination Complexes - toxicity
Cytotoxicity
Deoxyribonucleic acid
DFT calculations
DNA
DNA - chemistry
Drug resistance
Electrophoresis
Fungi - drug effects
Fungicides
Gel electrophoresis
Glycine
Imines
Interaction parameters
Leucine
Magnetic measurement
Mass spectra
Microbial Sensitivity Tests
Oxo-vanadium
Pyridines
Quantum Theory
Reagents
Salicylic Acid - chemistry
Salicylic Acid - pharmacology
Salicylic Acid - toxicity
Schiff base
Schiff Bases - chemistry
Sodium
Spectrophotometry
Strong interactions (field theory)
Toxicity
Tryptophan
Vanadium
Vanadium - chemistry
Vanadium - pharmacology
Vanadium - toxicity
title Biological potential of oxo-vanadium salicylediene amino-acid complexes as cytotoxic, antimicrobial, antioxidant and DNA interaction
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