Construction of electrochemical avenue for evaluating oxygen-carrying performance of a microsphere-based oxygen carrier with bovine serum albumin protection layer

The production of oxygen carriers is currently a topic of paramount interest in nanotechnology. Particularly, there is a focus in the development of microparticles with round and uniform shapes to further expand their potentialities. Here, we prepare homogenous microspheres with diameters of ~3μm us...

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Published in:Journal of electroanalytical chemistry (Lausanne, Switzerland) Switzerland), 2016-11, Vol.781, p.327-331
Main Authors: Lu, Yannan, Hu, Tingting, Wu, Tingting, Liu, Xiaojun, Bao, Ning, Yu, Chunmei, He, Hong, Gu, Haiying
Format: Article
Language:English
Subjects:
Analytical chemistry
Bovine serum albumin
Calcium carbonate
Crosslinking
Current carriers
Electrochemistry
Glutaraldehyde
Hemoglobin
Microparticles
Microspheres
Nanotechnology
Oxygen
Oxygen carriers
Serum albumin
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Summary:The production of oxygen carriers is currently a topic of paramount interest in nanotechnology. Particularly, there is a focus in the development of microparticles with round and uniform shapes to further expand their potentialities. Here, we prepare homogenous microspheres with diameters of ~3μm using porous calcium carbonate spheres as the template and glutaraldehyde as the cross-linking agent. Also, we present for the first time the use of electrochemical avenue to evaluate the oxygen-carrying ability of these as-prepared samples. Our results demonstrate successful construction of prospective microspheres which perform extraordinary oxygen-carrying capability with protection of bovine serum albumin layer on the surface. The homogenous Hb-BSA microspheres modified electrode exhibited excellent performance with enhanced capacity to store and transport oxygen compared with pure Hb-coated microspheres. The BSA molecule could improve the dispersity of the Hb-BSA microspheres and enhance their oxygen-carrying capacity. Furthermore, the utilization of electrochemistry for the study of our prepared Hb-BSA microspheres might be a novel effective approach for further application of oxygen carriers in electrochemical field. [Display omitted] •We fabricate uniform Hb-BSA microsphere using porous CaCO3 and glutaraldehyde.•Electrochemical study shows excellent oxygen-carrying ability of the microsphere.•BSA improves the dispersity of the microspheres and prevents agglomeration.
ISSN:1572-6657
1873-2569
DOI:10.1016/j.jelechem.2016.05.011