Electrochemical determination of paracetamol in presence of folic acid at nevirapine modified carbon paste electrode: A cyclic voltammetric study

• Published in: Journal of electroanalytical chemistry (Lausanne, Switzerland) Switzerland), 2017-08, Vol.798, p.17-23
• Main Authors: Tanuja, S.B., Kumara Swamy, B.E., Pai, K. Vasantakumar
• Format: Article
• Language: English
• Subjects: Analgesics; Bare carbon paste electrode (BCPE); Carbon; Cyclic voltammetry; Differential pulse voltammetry (DPV); Electrodes; Folic acid; Folic acid (FA); Nevirapine; Paracetamol (PA); Pharmaceuticals; Sensitivity enhancement; Vitamin B; Voltammetry
• ISSN: 1572-6657; 1873-2569
• DOI: 10.1016/j.jelechem.2017.05.025

The carbon paste electrode was modified by nevirapine drug, the voltammetric behaviour of paracetamol and folic acid at modified carbon paste electrode were investigated by cyclic voltammetric technique. The modified nevirapine carbon paste electrode showed an enhanced sensitivity towards paracetamol and folic acid. The modified nevirapine electrode had strong resolving capacity for overlapping voltammetric response of paracetamol and folic acid into two well resolved peaks, with increment of peak current as compared to the bare carbon paste electrode. The simultaneous determination of paracetamol in presence of folic acid without any interference is feasible at nevirapine modified carbon paste electrode, the detection limit of paracetamol and folic acid were found to be 0.77μM, 2.53μM respectively. The practical utility of the proposed electrode was evaluated by analysing paracetamol in pharmaceutical sample with satisfactory result. [Display omitted] •The carbon paste electrode was modified by nevirapine drug.•The electrochemical properties of the modified carbon paste electrode was investigated by cyclic voltammetry.•The modified carbon paste electrode revealed good selectivity and sensitivity•The detection limit of paracetamol was found to be 0.77 μM at modified carbon paste electrode.•The analytical applicability of the modified carbon paste was achieved for paracetamol in pharmaceutical preparation.