Bivariate GWAS Scan Identifies Six Novel Loci Associated with Lipid Levels and Coronary Artery Disease

Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely perform association studies of these traits independently of one another. Joint GWAS for two related phenotypes can lead to a higher-powe...

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Bibliographic Details
Published in:Human heredity 2018-06, Vol.83 (1), p.50
Main Authors: Siewert, K, Voight, B
Format: Article
Language:English
Subjects:
Cardiovascular disease
Cholesterol
Coronary artery
Coronary artery disease
Gene loci
Genome-wide association studies
Genomes
Genomics
Genotype & phenotype
Heart diseases
Lipids
Low density lipoprotein
Phenotypes
Plasma
Triglycerides
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Summary:Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely perform association studies of these traits independently of one another. Joint GWAS for two related phenotypes can lead to a higher-powered analysis to detect variants contributing to both traits. We performed a bivariate GWAS to discover novel loci associated with heart disease, using a CAD Meta-Analysis (122,733 cases and 424,528 controls), and lipid traits, using data from the Global Lipid Genetics Consortium (188,577 subjects). We identified six novel genome-wide significant loci, three which were associated with Triglycerides and CAD, two which were associated with LDL cholesterol and CAD, and one associated with Total Cholesterol and CAD. At several of our loci, the GWAS signals colocalize with expression level associations for one or more genes, indicating that these loci may be affecting disease risk through regulatory activity.
ISSN:0001-5652
1423-0062