Extracting Structural Information of a Heteropolymer from Force-Extension Curves

We present a theory for the reverse analysis on the sequence information of a single H/P two-letter random hetero-polymer (RHP) from its force-extension(f-z) curves during quasi static stretching. Upon stretching of a self-assembled RHP, it undergoes several structural transitions. The typical elast...

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Bibliographic Details
Published in:arXiv.org 2004-12
Main Authors: Jarkova, E, Nam-Kyung, Lee, Obukhov, S
Format: Article
Language:English
Subjects:
Domains
Self-assembly
Stretching
Online Access:Get full text
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Summary:We present a theory for the reverse analysis on the sequence information of a single H/P two-letter random hetero-polymer (RHP) from its force-extension(f-z) curves during quasi static stretching. Upon stretching of a self-assembled RHP, it undergoes several structural transitions. The typical elastic response of a hetero-polymeric globule is a set of overlapping saw-tooth patterns. With consideration of the height and the position of the overlapping saw-tooth shape, we analyze the possibility of extracting the binding energies of the internal domains and the corresponding block sizes of the contributing conformations.
ISSN:2331-8422
DOI:10.48550/arxiv.0412388