One Hub-One Process: A Tool Based View on Regulatory Network Topology

The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks. To quantify stru...

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Bibliographic Details
Published in:arXiv.org 2007-11
Main Authors: Jacob Bock Axelsen, Bernhardsson, Sebastian, Sneppen, Kim
Format: Article
Language:English
Subjects:
Baking yeast
Molecular structure
Network topologies
Networks
Proteins
Yeast
Online Access:Get full text
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Summary:The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks. To quantify structure-function relationship we investigate similarities of proteins which are close in the regulatory network of the yeast Saccharomyces Cerevisiae. We find that the topology of the regulatory network show weak remnants of its history of network reorganizations, but strong features of co-regulated proteins associated to similar tasks. This suggests that local topological features of regulatory networks, including broad degree distributions, emerge as an implicit result of matching a number of needed processes to a finite toolbox of proteins.
ISSN:2331-8422
DOI:10.48550/arxiv.0711.2208