A Growth Model for Multicellular Tumor Spheroids

Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m. Although this relation is generally recognized to be of the form B...

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Bibliographic Details
Published in:arXiv.org 2003-07
Main Authors: Delsanto, Pier Paolo, Guiot, Caterina, Degiorgis, Piero Giorgio, Condat, Carlos A, Mansury, Yuri, Deisboeck, Thomas S
Format: Article
Language:English
Subjects:
Energy conservation
Energy flow
Model testing
Spheroids
Tumors
Online Access:Get full text
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Summary:Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m. Although this relation is generally recognized to be of the form B(m) = mp, the specific value of the exponent p is the object of an ongoing debate, with many mechanisms being postulated to support different predictions. We propose that multicellular tumor spheroids provide an ideal experimental model system for testing these allometric growth theories, especially under controlled conditions of malnourishment and applied mechanical stress.
ISSN:2331-8422
DOI:10.48550/arxiv.0307136