Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology

We investigate the microscopic contact of a cell/semiconductor hybrid. The semiconductor is nanostructured with the aim of single channel recording of ion channels in cell membranes. This approach will overcome many limitations of the classical patch-clamp technique. The integration of silicon-based...

Full description

Saved in:
Bibliographic Details
Published in:arXiv.org 1999-10
Main Authors: Fertig, N, Tilke, A, Blick, R H, Kotthaus, J P, Behrends, J C, G ten Bruggencate
Format: Article
Language:English
Subjects:
Apertures
Cell membranes
Ion channels
Recording
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigate the microscopic contact of a cell/semiconductor hybrid. The semiconductor is nanostructured with the aim of single channel recording of ion channels in cell membranes. This approach will overcome many limitations of the classical patch-clamp technique. The integration of silicon-based devices 'on-chip' promises novel types of experiments on single ion channels.
ISSN:2331-8422