Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology

We investigate the microscopic contact of a cell/semiconductor hybrid. The semiconductor is nanostructured with the aim of single channel recording of ion channels in cell membranes. This approach will overcome many limitations of the classical patch-clamp technique. The integration of silicon-based...

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Published in:arXiv.org 1999-10
Main Authors: Fertig, N, Tilke, A, Blick, R H, Kotthaus, J P, Behrends, J C, G ten Bruggencate
Format: Article
Language:English
Subjects:
Apertures
Cell membranes
Ion channels
Recording
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creator Fertig, N
Tilke, A
Blick, R H
Kotthaus, J P
Behrends, J C
G ten Bruggencate
description We investigate the microscopic contact of a cell/semiconductor hybrid. The semiconductor is nanostructured with the aim of single channel recording of ion channels in cell membranes. This approach will overcome many limitations of the classical patch-clamp technique. The integration of silicon-based devices 'on-chip' promises novel types of experiments on single ion channels.
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subjects Apertures
Cell membranes
Ion channels
Recording
title Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology
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