Molecular Synchronization Waves in Arrays of Allosterically Regulated Enzymes

Spatiotemporal pattern formation in a product-activated enzymic reaction at high enzyme concentrations is investigated. Stochastic simulations show that catalytic turnover cycles of individual enzymes can become coherent and that complex wave patterns of molecular synchronization can develop. The an...

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Bibliographic Details
Published in:arXiv.org 2007-07
Main Authors: Casagrande, Vanessa, Togashi, Yuichi, Mikhailov, Alexander S
Format: Article
Language:English
Subjects:
Bifurcations
Catalysis
Enzymes
Synchronism
Online Access:Get full text
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Summary:Spatiotemporal pattern formation in a product-activated enzymic reaction at high enzyme concentrations is investigated. Stochastic simulations show that catalytic turnover cycles of individual enzymes can become coherent and that complex wave patterns of molecular synchronization can develop. The analysis based on the mean-field approximation indicates that the observed patterns result from the presence of Hopf and wave bifurcations in the considered system.
ISSN:2331-8422
DOI:10.48550/arxiv.0704.0021