One-pot multicomponent synthesis of novel thiazol-2-imines via microwave irradiation and their antifungal evaluation

Microwave-assisted green approach is developed for an efficient synthesis of thiazol-2-imines under catalyst-free conditions. The desired products are formed by one-pot three-component reaction which is an improvised method for Hantzsch thiazole synthesis. The microwave-assisted protocol gives excel...

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Bibliographic Details
Published in:Synthetic communications 2018-08, Vol.48 (16), p.2061-2073
Main Authors: Shaikh, Saba Kauser Jaweed, Kamble, Ravindra Ramappa, Somagond, Shilpa M., Kamble, Atulkumar A., Kumbar, Mahadev N.
Format: Article
Language:English
Subjects:
1,2,4-Triazolone
antifungal activity
Chemical synthesis
Fungicides
green synthesis
Imines
multicomponent reaction
thiazol-2-imines
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Summary:Microwave-assisted green approach is developed for an efficient synthesis of thiazol-2-imines under catalyst-free conditions. The desired products are formed by one-pot three-component reaction which is an improvised method for Hantzsch thiazole synthesis. The microwave-assisted protocol gives excellent yields with high purity in just 10-15 min. All the synthesized compounds have been screened for antifungal activity and some of the derivatives show a broad spectrum against fungal pathogens.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2018.1482348