Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding

Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list...

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Bibliographic Details
Published in:arXiv.org 2018-07
Main Authors: Waldman, Zachary J, Camarillo-Rodriguez, Liliana, Chervenova, Inna, Berry, Brent, Shimamoto, Shoichi, Elahian, Bahareh, Kucewicz, Michal, Ganne, Chaitanya, Xiao-Song, He, Davis, Leon A, Stein, Joel, Das, Sandhitsu, Gorniak, Richard, Sharan, Ashwini D, Gross, Robert, Inman, Cory S, Lega, Bradley C, Zaghloul, Kareem, Jobst, Barbara C, Davis, Katheryn A, Paul, Wanda, Khadjevand, Mehraneh, Tracy, Joseph, Rizzuto, Daniel S, Worrell, Gregory, Sperling, Michael, Weiss, Shennan A
Format: Article
Language:English
Subjects:
Coding
Convulsions & seizures
Correlation
Disruption
Epilepsy
Oscillations
Patients
Recall
Regression models
Seizures
Spikes
Statistical analysis
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Summary:Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch, and included the seizure onset zone (SOZ) as a covariate in the LRMs. Results: We detected events during 58,312 word presentation trials from 7,630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the seizure onset zone (SOZ, p
ISSN:2331-8422