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Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding
Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list...
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| creator | Waldman, Zachary J Camarillo-Rodriguez, Liliana Chervenova, Inna Berry, Brent Shimamoto, Shoichi Elahian, Bahareh Kucewicz, Michal Ganne, Chaitanya Xiao-Song, He Davis, Leon A Stein, Joel Das, Sandhitsu Gorniak, Richard Sharan, Ashwini D Gross, Robert Inman, Cory S Lega, Bradley C Zaghloul, Kareem Jobst, Barbara C Davis, Katheryn A Paul, Wanda Khadjevand, Mehraneh Tracy, Joseph Rizzuto, Daniel S Worrell, Gregory Sperling, Michael Weiss, Shennan A |
| description | Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch, and included the seizure onset zone (SOZ) as a covariate in the LRMs. Results: We detected events during 58,312 word presentation trials from 7,630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the seizure onset zone (SOZ, p |
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Methods: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch, and included the seizure onset zone (SOZ) as a covariate in the LRMs. Results: We detected events during 58,312 word presentation trials from 7,630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the seizure onset zone (SOZ, p<0.04). In the left temporal neocortex RonS events during word presentation corresponded with a decrease in the odds ratio (OR) of successful recall, however this effect only met significance in the SOZ (OR of word recall 0.71, 95% CI: 0.59-0.85, n=158 events, adaptive Hochberg p<0.01). Ripple on oscillation events (RonO) that occurred in the left temporal neocortex non-SOZ also correlated with decreased odds of successful recall (OR 0.52, 95% CI: 0.34-0.80, n=140, adaptive Hochberg , p<0.01). Spikes and RonS that occurred during word presentation in the left middle temporal gyrus during word presentation correlated with the most significant decrease in the odds of successful recall, irrespective of the location of the SOZ (adaptive Hochberg, p<0.01). Conclusion: Ripples and spikes generated in left temporal neocortex are associated with impaired verbal episodic memory encoding.</description><identifier>EISSN: 2331-8422</identifier><language>eng</language><publisher>Ithaca: Cornell University Library, arXiv.org</publisher><subject>Coding ; Convulsions & seizures ; Correlation ; Disruption ; Epilepsy ; Oscillations ; Patients ; Recall ; Regression models ; Seizures ; Spikes ; Statistical analysis</subject><ispartof>arXiv.org, 2018-07</ispartof><rights>2018. This work is published under http://arxiv.org/licenses/nonexclusive-distrib/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2092770668?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>780,784,25752,37011,44589</link.rule.ids></links><search><creatorcontrib>Waldman, Zachary J</creatorcontrib><creatorcontrib>Camarillo-Rodriguez, Liliana</creatorcontrib><creatorcontrib>Chervenova, Inna</creatorcontrib><creatorcontrib>Berry, Brent</creatorcontrib><creatorcontrib>Shimamoto, Shoichi</creatorcontrib><creatorcontrib>Elahian, Bahareh</creatorcontrib><creatorcontrib>Kucewicz, Michal</creatorcontrib><creatorcontrib>Ganne, Chaitanya</creatorcontrib><creatorcontrib>Xiao-Song, He</creatorcontrib><creatorcontrib>Davis, Leon A</creatorcontrib><creatorcontrib>Stein, Joel</creatorcontrib><creatorcontrib>Das, Sandhitsu</creatorcontrib><creatorcontrib>Gorniak, Richard</creatorcontrib><creatorcontrib>Sharan, Ashwini D</creatorcontrib><creatorcontrib>Gross, Robert</creatorcontrib><creatorcontrib>Inman, Cory S</creatorcontrib><creatorcontrib>Lega, Bradley C</creatorcontrib><creatorcontrib>Zaghloul, Kareem</creatorcontrib><creatorcontrib>Jobst, Barbara C</creatorcontrib><creatorcontrib>Davis, Katheryn A</creatorcontrib><creatorcontrib>Paul, Wanda</creatorcontrib><creatorcontrib>Khadjevand, Mehraneh</creatorcontrib><creatorcontrib>Tracy, Joseph</creatorcontrib><creatorcontrib>Rizzuto, Daniel S</creatorcontrib><creatorcontrib>Worrell, Gregory</creatorcontrib><creatorcontrib>Sperling, Michael</creatorcontrib><creatorcontrib>Weiss, Shennan A</creatorcontrib><title>Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding</title><title>arXiv.org</title><description>Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch, and included the seizure onset zone (SOZ) as a covariate in the LRMs. Results: We detected events during 58,312 word presentation trials from 7,630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the seizure onset zone (SOZ, p<0.04). In the left temporal neocortex RonS events during word presentation corresponded with a decrease in the odds ratio (OR) of successful recall, however this effect only met significance in the SOZ (OR of word recall 0.71, 95% CI: 0.59-0.85, n=158 events, adaptive Hochberg p<0.01). Ripple on oscillation events (RonO) that occurred in the left temporal neocortex non-SOZ also correlated with decreased odds of successful recall (OR 0.52, 95% CI: 0.34-0.80, n=140, adaptive Hochberg , p<0.01). Spikes and RonS that occurred during word presentation in the left middle temporal gyrus during word presentation correlated with the most significant decrease in the odds of successful recall, irrespective of the location of the SOZ (adaptive Hochberg, p<0.01). Conclusion: Ripples and spikes generated in left temporal neocortex are associated with impaired verbal episodic memory encoding.</description><subject>Coding</subject><subject>Convulsions & seizures</subject><subject>Correlation</subject><subject>Disruption</subject><subject>Epilepsy</subject><subject>Oscillations</subject><subject>Patients</subject><subject>Recall</subject><subject>Regression models</subject><subject>Seizures</subject><subject>Spikes</subject><subject>Statistical analysis</subject><issn>2331-8422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNissKwjAQAIMgKOo_LHgWYqqtnkXxLN4lxtVuSbMxG19_bw9-gKdhmOmpoSmK-Wy1MGagJiKN1tqUlVkui6HiA8XoEVgceW8zcRCgALlG8HjNkLGNnKyHgOw4ZXyDTQhWhB3ZjBd4Ua6B2mgpdfbEdO5ujCR8IQcttpw-gMF1Gm5j1b9aLzj5caSmu-1xs5_FxPcHSj41_EihSyej16aqdFmuiv-uLylwS5s</recordid><startdate>20180726</startdate><enddate>20180726</enddate><creator>Waldman, Zachary J</creator><creator>Camarillo-Rodriguez, Liliana</creator><creator>Chervenova, Inna</creator><creator>Berry, Brent</creator><creator>Shimamoto, Shoichi</creator><creator>Elahian, Bahareh</creator><creator>Kucewicz, Michal</creator><creator>Ganne, Chaitanya</creator><creator>Xiao-Song, He</creator><creator>Davis, Leon A</creator><creator>Stein, Joel</creator><creator>Das, Sandhitsu</creator><creator>Gorniak, Richard</creator><creator>Sharan, Ashwini D</creator><creator>Gross, Robert</creator><creator>Inman, Cory S</creator><creator>Lega, Bradley C</creator><creator>Zaghloul, Kareem</creator><creator>Jobst, Barbara C</creator><creator>Davis, Katheryn A</creator><creator>Paul, Wanda</creator><creator>Khadjevand, Mehraneh</creator><creator>Tracy, Joseph</creator><creator>Rizzuto, Daniel S</creator><creator>Worrell, Gregory</creator><creator>Sperling, Michael</creator><creator>Weiss, Shennan A</creator><general>Cornell University Library, arXiv.org</general><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>M7S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope></search><sort><creationdate>20180726</creationdate><title>Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding</title><author>Waldman, Zachary J ; Camarillo-Rodriguez, Liliana ; Chervenova, Inna ; Berry, Brent ; Shimamoto, Shoichi ; Elahian, Bahareh ; Kucewicz, Michal ; Ganne, Chaitanya ; Xiao-Song, He ; Davis, Leon A ; Stein, Joel ; Das, Sandhitsu ; Gorniak, Richard ; Sharan, Ashwini D ; Gross, Robert ; Inman, Cory S ; Lega, Bradley C ; Zaghloul, Kareem ; Jobst, Barbara C ; Davis, Katheryn A ; Paul, Wanda ; Khadjevand, Mehraneh ; Tracy, Joseph ; Rizzuto, Daniel S ; Worrell, Gregory ; Sperling, Michael ; Weiss, Shennan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_20927706683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Coding</topic><topic>Convulsions & seizures</topic><topic>Correlation</topic><topic>Disruption</topic><topic>Epilepsy</topic><topic>Oscillations</topic><topic>Patients</topic><topic>Recall</topic><topic>Regression models</topic><topic>Seizures</topic><topic>Spikes</topic><topic>Statistical analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Waldman, Zachary J</creatorcontrib><creatorcontrib>Camarillo-Rodriguez, Liliana</creatorcontrib><creatorcontrib>Chervenova, Inna</creatorcontrib><creatorcontrib>Berry, Brent</creatorcontrib><creatorcontrib>Shimamoto, Shoichi</creatorcontrib><creatorcontrib>Elahian, Bahareh</creatorcontrib><creatorcontrib>Kucewicz, Michal</creatorcontrib><creatorcontrib>Ganne, Chaitanya</creatorcontrib><creatorcontrib>Xiao-Song, He</creatorcontrib><creatorcontrib>Davis, Leon A</creatorcontrib><creatorcontrib>Stein, Joel</creatorcontrib><creatorcontrib>Das, Sandhitsu</creatorcontrib><creatorcontrib>Gorniak, Richard</creatorcontrib><creatorcontrib>Sharan, Ashwini D</creatorcontrib><creatorcontrib>Gross, Robert</creatorcontrib><creatorcontrib>Inman, Cory S</creatorcontrib><creatorcontrib>Lega, Bradley C</creatorcontrib><creatorcontrib>Zaghloul, Kareem</creatorcontrib><creatorcontrib>Jobst, Barbara C</creatorcontrib><creatorcontrib>Davis, Katheryn A</creatorcontrib><creatorcontrib>Paul, Wanda</creatorcontrib><creatorcontrib>Khadjevand, Mehraneh</creatorcontrib><creatorcontrib>Tracy, Joseph</creatorcontrib><creatorcontrib>Rizzuto, Daniel S</creatorcontrib><creatorcontrib>Worrell, Gregory</creatorcontrib><creatorcontrib>Sperling, Michael</creatorcontrib><creatorcontrib>Weiss, Shennan A</creatorcontrib><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waldman, Zachary J</au><au>Camarillo-Rodriguez, Liliana</au><au>Chervenova, Inna</au><au>Berry, Brent</au><au>Shimamoto, Shoichi</au><au>Elahian, Bahareh</au><au>Kucewicz, Michal</au><au>Ganne, Chaitanya</au><au>Xiao-Song, He</au><au>Davis, Leon A</au><au>Stein, Joel</au><au>Das, Sandhitsu</au><au>Gorniak, Richard</au><au>Sharan, Ashwini D</au><au>Gross, Robert</au><au>Inman, Cory S</au><au>Lega, Bradley C</au><au>Zaghloul, Kareem</au><au>Jobst, Barbara C</au><au>Davis, Katheryn A</au><au>Paul, Wanda</au><au>Khadjevand, Mehraneh</au><au>Tracy, Joseph</au><au>Rizzuto, Daniel S</au><au>Worrell, Gregory</au><au>Sperling, Michael</au><au>Weiss, Shennan A</au><format>book</format><genre>document</genre><ristype>GEN</ristype><atitle>Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding</atitle><jtitle>arXiv.org</jtitle><date>2018-07-26</date><risdate>2018</risdate><eissn>2331-8422</eissn><abstract>Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding. Methods: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch, and included the seizure onset zone (SOZ) as a covariate in the LRMs. Results: We detected events during 58,312 word presentation trials from 7,630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the seizure onset zone (SOZ, p<0.04). In the left temporal neocortex RonS events during word presentation corresponded with a decrease in the odds ratio (OR) of successful recall, however this effect only met significance in the SOZ (OR of word recall 0.71, 95% CI: 0.59-0.85, n=158 events, adaptive Hochberg p<0.01). Ripple on oscillation events (RonO) that occurred in the left temporal neocortex non-SOZ also correlated with decreased odds of successful recall (OR 0.52, 95% CI: 0.34-0.80, n=140, adaptive Hochberg , p<0.01). Spikes and RonS that occurred during word presentation in the left middle temporal gyrus during word presentation correlated with the most significant decrease in the odds of successful recall, irrespective of the location of the SOZ (adaptive Hochberg, p<0.01). Conclusion: Ripples and spikes generated in left temporal neocortex are associated with impaired verbal episodic memory encoding.</abstract><cop>Ithaca</cop><pub>Cornell University Library, arXiv.org</pub><oa>free_for_read</oa></addata></record> |
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| subjects | Coding Convulsions & seizures Correlation Disruption Epilepsy Oscillations Patients Recall Regression models Seizures Spikes Statistical analysis |
| title | Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding |
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