Influence of Nanocluster Molybdenum Polyoxometalates on the Morphofunctional State of Fibroblasts in Culture

For the culture of normal and transformed fibroblasts, the differential effect of two nanoclusters (Мо 72 Fe 30 , Мо 132 ) has been shown. The Мо 72 Fe 30 nanocluster is nontoxic to normal fibroblasts, while the Мо 132 cluster shows toxicity to normal and transformed fibroblasts. An analysis of the...

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Bibliographic Details
Published in:Nanotechnologies in Russia 2018, Vol.13 (1-2), p.1-10
Main Authors: Ostroushko, A. A., Ulitko, M. V., Tonkushina, M. O., Zubarev, I. V., Medvedeva, S. Yu, Danilova, I. G., Gubaeva, O. V., Gagarin, I. D., Gette, I. F.
Format: Article
Language:English
Subjects:
Biocompatibility
Chemistry and Materials Science
Clusters
Fibroblasts
Industrial and Production Engineering
Machines
Manufacturing
Materials Science
Nanoclusters
Nanotechnology
Organelles
Polyoxometallates
Processes
Toxicity
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Summary:For the culture of normal and transformed fibroblasts, the differential effect of two nanoclusters (Мо 72 Fe 30 , Мо 132 ) has been shown. The Мо 72 Fe 30 nanocluster is nontoxic to normal fibroblasts, while the Мо 132 cluster shows toxicity to normal and transformed fibroblasts. An analysis of the ultrastructure of the cells under the influence of the nanoclusters has demonstrated the specificity of the changes. The dermal fibroblasts are more resistant to the action of Мо 72 Fe 30 ; the Мо 132 cluster causes extensive disorders in the membrane organelles both in normal and transformed fibroblasts. The results confirm the possibility of applying the Мо 72 Fe 30 nanocluster in biomedicine and the use of the Мо 132 nanocluster in oncology.
ISSN:1995-0780
1995-0799
DOI:10.1134/S199507801801010X