Using Molecular Models To Assess Agonists and Antagonists for Cell-Surface Receptors

A series of tabletop models was built to demonstrate the interactions between a fictional cell-surface receptor, the receptor’s natural ligand, and eight potential therapeutic agents. Students assessed the eight therapeutic agents as agonists, antagonists, or neither agonists nor antagonists, first...

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Bibliographic Details
Published in:Journal of chemical education 2018-07, Vol.95 (7), p.1156-1160
Main Authors: Schwert, Daniel D, Gruenbaum, Scott M
Format: Article
Language:English
Subjects:
Antagonist drugs
Biochemistry
Chemical compounds
Exercise
Ligands
Pharmacology
Receptors
Students
Three dimensional models
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Summary:A series of tabletop models was built to demonstrate the interactions between a fictional cell-surface receptor, the receptor’s natural ligand, and eight potential therapeutic agents. Students assessed the eight therapeutic agents as agonists, antagonists, or neither agonists nor antagonists, first as a pencil-and-paper exercise and then subsequently using the three-dimensional models. Students found the activity to be engaging and were more accurately able to identify the correct roles of the agents when using the models.
ISSN:0021-9584
1938-1328
DOI:10.1021/acs.jchemed.7b00980