Free-Radical Damage: A Possible Mechanism of Laryngeal Aging

We conducted a study of lipid peroxidation as a marker of age-related free-radical damage in the human larynx—the first study of its kind. A colorimetric assay for malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) was performed on extracts taken from thyroarytenoid muscle harvested from fresh ca...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2002-08, Vol.81 (8), p.531-533
Main Authors: Diamond, Jason, Skaggs, Jennifer, Manaligod, Jose M.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Aging - physiology
Aldehydes - analysis
Aldehydes - metabolism
Biological and medical sciences
Cadaver
Culture Techniques
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Female
Free radicals (Chemistry)
Free Radicals - adverse effects
Fundamental and applied biological sciences. Psychology
Health aspects
Humans
Larynx
Larynx - metabolism
Larynx - physiopathology
Linear Models
Lipid peroxidation
Lipid Peroxidation - physiology
Male
Malondialdehyde - analysis
Malondialdehyde - metabolism
Middle Aged
Oxidative Stress
Physiological aspects
Sensitivity and Specificity
Spectrophotometry
Vertebrates: nervous system and sense organs
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Summary:We conducted a study of lipid peroxidation as a marker of age-related free-radical damage in the human larynx—the first study of its kind. A colorimetric assay for malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) was performed on extracts taken from thyroarytenoid muscle harvested from fresh cadaveric laryngeal specimens. Levels of MDA and 4-HNE were measured by spectrophotometry. Correlation studies were performed by linear regression analysis. We found that MDA levels in human thyroarytenoid muscle appeared to increase with age while 4-HNE levels showed a slight decrease with age. Our findings are consistent with those of previous studies of other organ systems and indicate that there is a need for further study of free-radical damage and the effects of aging on the human larynx and on voice production.
ISSN:0145-5613
1942-7522
DOI:10.1177/014556130208100813