The Role of Radioactive Iodine in Salivary Gland Dysfunction

The use of radioactive iodine has become an important adjunct to the treatment of thyroid cancer. Many normal tissues—including salivary glands, gastrointestinal mucosa, gonads, and lactating breast tissue—have the ability to concentrate radioactive iodine under normal circumstances. Although the me...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2000-06, Vol.79 (6), p.460-468
Main Authors: Newkirk, Kenneth A., Ringel, Matthew D., Wartofsky, Leonard, Burman, Kenneth D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Care and treatment
Complications and side effects
Cytoprotection
Drug toxicity and drugs side effects treatment
Endocrinopathies
Humans
Iodine
Iodine Radioisotopes - adverse effects
Iodine Radioisotopes - therapeutic use
Isotopes
Malignant tumors
Medical sciences
Pharmacology. Drug treatments
Radiotherapy
Saliva
Salivary Gland Diseases - chemically induced
Salivary Gland Diseases - physiopathology
Salivary Gland Diseases - prevention & control
Salivary glands
Salivary Glands - anatomy & histology
Salivary Glands - physiology
secretions
Thyroid cancer
Thyroid Neoplasms - drug therapy
Thyroid. Thyroid axis (diseases)
Toxicity: respiratory system, ent, stomatology
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Summary:The use of radioactive iodine has become an important adjunct to the treatment of thyroid cancer. Many normal tissues—including salivary glands, gastrointestinal mucosa, gonads, and lactating breast tissue—have the ability to concentrate radioactive iodine under normal circumstances. Although the mechanism is just beginning to be elucidated, it is this ability that might contribute to the immediate and long-term complications associated with radioactive iodine treatment. In some patients, the salivary complications can be permanent and might compromise daily functioning. In this article, we examine the salivary gland complications associated with radioactive iodine therapy, and we suggest potential protective mechanisms to circumvent these problems.
ISSN:0145-5613
1942-7522
DOI:10.1177/014556130007900612