In vitro assessment of hepatotoxicity by metabolomics: a review

Omics technologies, and in particular metabolomics, have received an increasing attention during the assessment of hepatotoxicity in vitro. However, at present, a consensus on good metabolomics practices has yet to be reached. Therefore, in this review, a range of experimental approaches, applied me...

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Bibliographic Details
Published in:Archives of toxicology 2018-10, Vol.92 (10), p.3007-3029
Main Authors: Cuykx, Matthias, Rodrigues, Robim M., Laukens, Kris, Vanhaecke, Tamara, Covaci, Adrian
Format: Article
Language:English
Subjects:
Alanine
Annotations
Apoptosis
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cell lines
Choline
Confidence
Data analysis
Data processing
Environmental Health
Filtration
Glutathione
Hepatocytes
Hepatotoxicity
Krebs cycle
Lactic acid
Liver
Metabolites
Metabolomics
Occupational Medicine/Industrial Medicine
Oxidative stress
Pharmacology/Toxicology
Phospholipids
Proline
Proteins
Quality control
Review Article
Spectrometry
Steatosis
Toxicity
Toxicology
Tricarboxylic acid cycle
Tryptophan
Valine
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Summary:Omics technologies, and in particular metabolomics, have received an increasing attention during the assessment of hepatotoxicity in vitro. However, at present, a consensus on good metabolomics practices has yet to be reached. Therefore, in this review, a range of experimental approaches, applied methodologies, and data processing workflows are compared and critically evaluated. Experimental designs among the studies are similar, reporting the use of primary hepatocytes or hepatic cell lines as the most frequently used cell sources. Experiments are usually conducted in short time-frames (
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-018-2286-9