Albendazole and Mebendazole as an Alternative Therapeutic Agent for Adult Giardiasis

We examined the therapeutic effects of albendazole. metronidazole and mebenazole 183 patients with giardiasis in Tehran Province. Patients were randomized to receive albendazole (400 mg, once daily for 5 days) or metronidazole (250 mg, 3 times a day for 5 days) or mebendazole (200 mg, 2 times a day...

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Published in:Biosciences, biotechnology research Asia biotechnology research Asia, 2016-06, Vol.13 (2), p.961-965
Main Authors: Shokouh, Seyyed Javad Hosseini, Ahmadi, Mossa
Format: Article
Language:English
Subjects:
Albendazole
Chemical compounds
Clinical trials
Cysts
Demographics
Family medical history
Giardia
Giardiasis
Mebendazole
Metronidazole
Parasites
Patients
Pediatrics
Pharmacology
Secondary school students
Secondary schools
Side effects
Statistical analysis
Trophozoites
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Summary:We examined the therapeutic effects of albendazole. metronidazole and mebenazole 183 patients with giardiasis in Tehran Province. Patients were randomized to receive albendazole (400 mg, once daily for 5 days) or metronidazole (250 mg, 3 times a day for 5 days) or mebendazole (200 mg, 2 times a day for 5 days) . Demographic data of the patients, results of stool exa­mination for Giardia (cyst or trophozoites ) before and after treatment, and drug side-effects were recorded. The final results showed that albendazole (93%) and mebendazole ( 89% ) and metronidazole (95.5%) have similar therapeutic effects on giardiasis . Patients in the albendazole group(19.7%) had fewer side-effects compared with metronidazole (39%) & mebendazole groups (27%) . This difference is statistically significant (p < 0.01). We offer the albendazole as a grug of choice of giardiasis.
ISSN:0973-1245
2456-2602
DOI:10.13005/bbra/2121