HEALTH STATE UTILITY VALUES FOR HER2+ METASTATIC BREAST CANCER

OBJECTIVES: Health state utility values (HSUV) are commonly used to derive quality adjusted life years in economic evaluations. The objective of this study was to estimate health utilities for HER2+ metastatic breast cancer patients who have failed on least two regimens of HER2 directed therapies. M...

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Bibliographic Details
Published in:Value in health 2017-05, Vol.20 (5), p.A115
Main Authors: Paracha, N, Thuresson, P, Ray, J
Format: Article
Language:English
Subjects:
Body mass index
Breast cancer
Clinical outcomes
Critical incidents
Data processing
Death & dying
ErbB-2 protein
Health status
Hospitalization
Metastases
Metastasis
Patients
Proximity
Quality adjusted life years
Quality of life
Statistical analysis
Values
Variables
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Summary:OBJECTIVES: Health state utility values (HSUV) are commonly used to derive quality adjusted life years in economic evaluations. The objective of this study was to estimate health utilities for HER2+ metastatic breast cancer patients who have failed on least two regimens of HER2 directed therapies. METHODS: We analysed data from a large (n=602), repeated measure (3,767 observations), EQ-5D-3L dataset from the TH3RESA trial to estimate utility values. The EQ-5D was converted into utility value using the UK tariff. A mixed (random-slope) models using unstructured covariance structure were fitted to predict utility values according to baseline patient characteristics and key clinical outcomes. The set of variables considered for the model included: treatment allocation, disease progression, hospitalisation due to adverse event (AE), baseline age, baseline ECOG, sex, baseline BMI, number of prior regimen (3), visceral disease, and patient proximity to death. Final set of variables were selected using clinical opinion. RESULTS: The median number of follow up visit was 7 (range: 0-27). Time was included as a random effect. Included variables demonstrated evidence of an important association with HRQoL outcomes based on magnitude and significance of effect (p
ISSN:1098-3015
1524-4733
DOI:10.1016/j.jval.2017.05.005