Dimethyl fumarate‐induced IL‐17lowIFN‐γlowIL‐4+ Th cells protect mice from severe encephalomyelitis

Dimethyl fumarate (DMF) promotes an IL‐17AlowIFN‐γlowIL‐4+ CD4+ T cell phenotype. Adoptive transfer of in vitro DMF‐treated myelin peptide‐reactive IL‐17AlowIFN‐γlowIL‐4+ CD4+ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF‐t...

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Bibliographic Details
Published in:European journal of immunology 2018-09, Vol.48 (9), p.1588-1591
Main Authors: Brück, Jürgen, Glocova, Ivana, Geisel, Julia, Kellerer, Christina, Röcken, Martin, Ghoreschi, Kamran
Format: Article
Language:English
Subjects:
Adoptive transfer
CD4 antigen
Dimethyl fumarate
EAE
Experimental allergic encephalomyelitis
Helper cells
Immunization
Immunotherapy
Lymphocytes
Lymphocytes T
Myelin
Phenotypes
T cell vaccine
Th17 cells
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Summary:Dimethyl fumarate (DMF) promotes an IL‐17AlowIFN‐γlowIL‐4+ CD4+ T cell phenotype. Adoptive transfer of in vitro DMF‐treated myelin peptide‐reactive IL‐17AlowIFN‐γlowIL‐4+ CD4+ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF‐treated CD4+ T cells requires an early in vivo recall.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201747435