EFFECT OF SMOKING ON INTERLEUKIN-6 IN SPRAGUE DAWLEY RATS

Objective: To investigate the effect of cigarette smoking on interleukin-6 in Sprague Dawley rats.Study Design: Randomized controlled study.Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan to Apr 2015.Material and Methods: Seventy healthy male Sprague Daw...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2018-06 (3), p.658-663
Main Authors: Jamil, Aneela, Rashid, Amir, Naveed, Abdul Khaliq
Format: Article
Language:English
Subjects:
B cells
Biomarkers
Cigarettes
Cytokines
Enzyme-linked immunosorbent assay
Health risk assessment
Interleukins
Kinases
Medical schools
Rodents
Smoking
Tobacco smoke
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Summary:Objective: To investigate the effect of cigarette smoking on interleukin-6 in Sprague Dawley rats.Study Design: Randomized controlled study.Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan to Apr 2015.Material and Methods: Seventy healthy male Sprague Dawley rats were randomly divided into two groups at National Institute of Health (NIH). Group-I rats were not exposed while group-II rats were exposed to cigarette smoke for 3 months. Interleukin-6 (IL-6) was determined using commercially available enzyme linked immunosorbent assay (ELISA) kit. Data was analyzed using t-test.Results: Higher levels of IL-6 were observed in exposed than in non-exposed. The mean of IL-6 levels of control and smoker groups was 40.84 ± 9.09 and 49.48 ± 19.69 respectively. The difference was statistically significant (p
ISSN:0030-9648
2411-8842