Microwave Assisted Synthesis and Antimicrobial Activity of (E)-1-{2/3/4-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones

A novel series of ( E )-1-{2/3/4-[(1-aryl-1 H -1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones is synthesised from terminal alkynes with aromatic azides by the Click reaction in the presence of copper sulphate and sodium ascorbate in DMF: water under microwave irradi...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-07, Vol.88 (7), p.1502-1507
Main Authors: Pujari, Vijay Kumar, Vinnakota, Srilalitha, Kakarla, Ramana Kumar, Maroju, Sreedhar, Ganesh, Arram, Pervaram, S.
Format: Article
Language:English
Subjects:
Alkynes
Antiinfectives and antibacterials
Antimicrobial agents
Aromatic compounds
Chemical reactions
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Mass spectra
NMR
Nuclear magnetic resonance
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Summary:A novel series of ( E )-1-{2/3/4-[(1-aryl-1 H -1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones is synthesised from terminal alkynes with aromatic azides by the Click reaction in the presence of copper sulphate and sodium ascorbate in DMF: water under microwave irradiation. All the synthesised compounds are characterised by IR, 1 H and 13 C NMR, and mass spectra, and tested in vitro for antimicrobial activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363218070241