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Ultrasound-assisted rapid synthesis of [beta]-cyanoepoxides using hypervalent iodine reagents
An elegant approach for the rapid synthesis of [beta]-cyanoepoxides 3 by the epoxidation of [beta]-cyanostyrenes 1 with PIDA 2a is described. The epoxidation of [beta]-cyanostyrenes 1 was performed with 1.2 equiv. of PIDA 2a in MeCN-H2O (1:1) at room temperature in ultrasonic bath. The epoxidation r...
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Published in: | Synthetic communications 2018-09, Vol.48 (17), p.2169 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | An elegant approach for the rapid synthesis of [beta]-cyanoepoxides 3 by the epoxidation of [beta]-cyanostyrenes 1 with PIDA 2a is described. The epoxidation of [beta]-cyanostyrenes 1 was performed with 1.2 equiv. of PIDA 2a in MeCN-H2O (1:1) at room temperature in ultrasonic bath. The epoxidation reactions were completed in short reaction time and [beta]-cyanoepoxides 3 were isolated in 69-94% yields. |
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ISSN: | 0039-7911 1532-2432 |
DOI: | 10.1080/00397911.2018.1479760 |