Association between BNP levels and new-onset atrial fibrillation

• Published in: Herz 2018-09, Vol.43 (6), p.548-554
• Main Authors: Karabağ, Y, Rencuzogullari, I, Çağdaş, M, Karakoyun, S, Yesin, M, Uluganyan, M, Gürsoy, M O, Artaç, İnanç, Doğan İliş, Gökdeniz, Tayyar, Efe, S Ç, Taşar, O, Tanboğa, H İ
• Format: Article
• Language: English
• Subjects: Brain natriuretic peptide; Cardiac arrhythmia; Confidence intervals; Fibrillation; Health risk assessment; Mortality; Myocardial infarction; Patients; Plasma; Population studies; Prognosis; Risk analysis; Risk factors
• ISSN: 0340-9937; 1615-6692
• DOI: 10.1007/s00059-017-4598-6

BackgroundNew-onset atrial fibrillation (NOAF), a common complication of acute ST-segment elevation myocardial infarction (STEMI), is associated with a poor prognosis. Several clinical and laboratory parameters are reported to be associated with NOAF in patients with STEMI. The aim of the present study was to evaluate the predictive value of plasma B‑type natriuretic peptide (BNP) levels for NOAF development and long-term prognosis in STEMI patients undergoing primary percutaneous coronary intervention (pPCI).Patients and methodsWe retrospectively enrolled 1,928 patients with STEMI who underwent pPCI. After applying exclusion criteria, 1,057 patients were retained in the final study population. Patients with NOAF were compared with patients without NOAF in the entire study population and in a matched group.ResultsPatients with NOAF had a significantly higher average plasma BNP level (161 pg/ml, range: 72.3–432) than patients without NOAF in the study population (70.7 pg/ml, range: 70–129; p < 0.001) and in the matched group (104.6 pg/ml, range: 47.2–234.5; p = 0.014). Furthermore, the plasma BNP level was found to be an independent predictor of NOAF development (odds ratio [OR]: 1.003; 95% confidence interval [CI]: 1.000–1.005; p = 0.034) and mortality in the long-term follow-up (OR: 1.004; 95% CI: 1.002–1.006; p < 0.001).ConclusionThe present study found that a high plasma BNP level was significantly associated with NOAF development in STEMI patients, and was an independent predictor of NOAF development and all-cause mortality during long-term follow-up, regardless of other NOAF risk factors.