Applications of steroid drugs entrapped in cyclodextrins

Steroids are abundant in living organisms and are responsible for various biological functions. They are good candidates for inclusion complexes formation with cyclodextrins; therefore, plenty of literature describes these complexes and their application in various fields. There are, however, hardly...

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Bibliographic Details
Published in:Environmental chemistry letters 2019-03, Vol.17 (1), p.375-391
Main Authors: Fenyvesi, Éva, Puskás, István, Szente, Lajos
Format: Article
Language:English
Subjects:
Anaesthesia
Analytical Chemistry
Anesthesia
Bioavailability
Biotechnology
Biotransformation
Catalysis
Catalysts
Chemical kinetics
Complexation
Contraceptives
Cyclodextrin
Cyclodextrins
Data processing
Drugs
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Formulations
Geochemistry
Impaired risk
Inclusion complexes
Pharmacokinetics
Pharmacology
Pollution
Review
Sorbents
Stability
Steroid hormones
Steroids
Underwriting
Wastewater
Wastewater purification
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Summary:Steroids are abundant in living organisms and are responsible for various biological functions. They are good candidates for inclusion complexes formation with cyclodextrins; therefore, plenty of literature describes these complexes and their application in various fields. There are, however, hardly any reviews summarizing this tremendous amount of information. Here, we review steroid drugs in relation to their complexation with cyclodextrins, highlighting the effect of cyclodextrin–steroid interaction on the solubility, stability and bioavailability of the entrapped steroid drugs. We have collected data on the changes in the pharmacokinetics of cyclodextrin-formulated steroid drugs designed for various routes of administration. We show some cyclodextrin-enabled steroid formulations introduced to the market. Sugammadex, the first cyclodextrin derivative approved as active pharmaceutical ingredient, which revolutionized anesthesia, is also discussed. Several examples demonstrate the catalysis and inhibition of various biotransformation reactions of steroids by cyclodextrin complexation used in biotechnology. The laboratory- and pilot-scale experiments for environmental application of cyclodextrin–steroid interaction are based on cyclodextrin-containing sorbents for capturing residual steroid drugs, such as contraceptives from purified wastewater.
ISSN:1610-3653
1610-3661
DOI:10.1007/s10311-018-0807-7