Biosensors: The advanced molecular probes - A meta-analysis over a decade

• Published in: Journal of medicine, radiology, pathology and surgery radiology, pathology and surgery, 2016, Vol.2 (1), p.16-19
• Main Authors: Gaurav, Naik, Vathsala, Sodhi, Amandeep
• Format: Article
• Language: English
• Subjects: Acids; Biosensors; Cell division; Collaboration; Iodine; Medical prognosis; Meta-analysis; Nanotechnology; Oral cancer; Proteins; Software; Visual aids
• ISSN: 2395-2075; 2395-2075
• DOI: 10.15713/ins.jmrps.46

To statistically demonstrate the enhanced specificity and sensitivity of Biosensors over other comparative investigative procedures for detection of oral precancer over a decade. Study sample included a review of research articles, based on databases from the Cochrane collaboration having a definite randomized control trial, on various investigative procedures for oral pre-cancer lesions and conditions and oral cancer itself over the past decade. This included literature on toluidine blue, Lugol's iodine, Vizilite, Velscope, Colposcopy, and Biosensors - The mainstay of the intended study. The literature was assessed, analyzed, and studied; the comparison was made based on the various P values between various techniques on one side and biosensors on the other in terms of sensitivity and specificity. A meta-analysis of all the modalities including the above-mentioned parameters was carried out and advantages and disadvantages documented and compared with those of Biosensors to demonstrate the title of the study. Compared to the 100% sensitivity and specificity of biosensors, the sensitivity, and specificity of vital staining techniques were found to be, respectively, 95% and 81%, whereas the sensitivity and specificity of visual aids were found to be, respectively, 86% and 78%. Biosensors definitely came up as the best diagnostic aids and investigative procedures at hand compared to all others existing or tried so far.