Value of 18 F-FET PET in adult brainstem glioma

To investigate F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUV , TBR, and time activ...

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Bibliographic Details
Published in:Clinical imaging 2018-09, Vol.51, p.68
Main Authors: Albatly, Abdulrahman Abdullah, Alsamarah, Adnan Taleb, Alhawas, Abdulrahman, Veit-Haibach, Patrick, Buck, Alfred, Stolzmann, Paul, Burger, Irene A, Kollias, Spyros S, Huellner, Martin W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Age
Amino acids
Brain cancer
Brain Neoplasms - diagnostic imaging
Brain stem
Brain Stem - diagnostic imaging
Brain tumors
Consent
Disease Progression
Disease-Free Survival
Emission analysis
Ethics
Female
Glioma
Glioma - diagnostic imaging
Histopathology
Humans
Male
Medical imaging
Medical prognosis
Middle Aged
Patients
Pediatrics
Positron emission
Positron emission tomography
Positron-Emission Tomography - methods
Spinal cord
Studies
Tomography
Tumors
Tyrosine
Tyrosine - analogs & derivatives
Tyrosine - pharmacology
Young Adult
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Summary:To investigate F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUV , TBR, and time activity curves of FET-PET were calculated. Progressive gliomas had higher SUV (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBR (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBR   2.0 (665 ± 32 days versus 220 ± 39 days; p 
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2018.01.015