Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta‐analysis

Background Mothers of preterm infants often struggle to produce enough breast milk to meet the nutritional needs of their infant. Galactagogues such as domperidone are often prescribed to increase breast milk supply but evidence supporting their role in clinical practice is uncertain. Objective To e...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2018-10, Vol.125 (11), p.1371-1378
Main Authors: Grzeskowiak, LE, Smithers, LG, Amir, LH, Grivell, RM
Format: Article
Language:English
Subjects:
Adult
Breast feeding
Breast milk
Breast Milk Expression - methods
Breastfeeding & lactation
Clinical trials
Data processing
domperidone
Domperidone - therapeutic use
Drug therapy
Evidence-based medicine
Female
galactogogue
Gestation
Gynecology
human
Humans
infant
Infant, Newborn
Infant, Premature
Infants
Lactation - drug effects
Meta-analysis
milk
milk supply
Milk, Human - drug effects
Newborn babies
premature
Premature babies
Sensitivity analysis
Systematic review
Treatment Outcome
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Summary:Background Mothers of preterm infants often struggle to produce enough breast milk to meet the nutritional needs of their infant. Galactagogues such as domperidone are often prescribed to increase breast milk supply but evidence supporting their role in clinical practice is uncertain. Objective To evaluate the efficacy and safety of domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants. Search strategy MEDLINE, Embase and Web of Science were searched without language restrictions from first publication until January 2017. Bibliographies of articles and reviews were hand‐searched for additional reports. Selection criteria Randomised controlled trials that compared domperidone with placebo in mothers of preterm infants (
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.15177