Microbial Transformation of Some Steroids by Cladosporium Cladosporioides Mrc 70282

Incubation of testosterone, androstenedione and progesterone with Cladosporium cladosporioides MRC 70282 for 5 days is reported. Testosterone was hydroxylated at C-16β and then oxidised at C-16. This was accompanied by a minor independent oxidation at C-17 and epimerisation at C-17. Androstenedione...

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Bibliographic Details
Published in:Journal of chemical research 2018-08, Vol.42 (8), p.408-411
Main Authors: Yildirim, Kudret, Kuru, Ali, Yılmaz, Raşit Fikret
Format: Article
Language:English
Subjects:
Microorganisms
Oxidation
Steroids
Testosterone
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Summary:Incubation of testosterone, androstenedione and progesterone with Cladosporium cladosporioides MRC 70282 for 5 days is reported. Testosterone was hydroxylated at C-16β and then oxidised at C-16. This was accompanied by a minor independent oxidation at C-17 and epimerisation at C-17. Androstenedione was reduced at C-17 and hydroxylated at C-16β, and this was then oxidised to a ketone at C-16. This was accompanied by a minor epimerisation at C-17. Progesterone was hydroxylated at C-21, and this was accompanied by a minor independent 5α-reduction.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751918X15337219180719