Serum and aqueous humor concentrations of interleukin-27 in diabetic retinopathy patients

Purpose Interleukin (IL)-27 has been reported to possess anti- and proinflammatory properties in several immune related-disorders, but its role in diabetic retinopathy is still elusive. Here, we aimed to (i) evaluate IL-27 concentrations in serum and aqueous humor of diabetic patients with or withou...

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Bibliographic Details
Published in:International ophthalmology 2018-10, Vol.38 (5), p.1817-1823
Main Authors: Houssen, Maha E., El-Hussiny, Mona Abo Bakr, El-Kannishy, Amr, Sabry, Dalia, El Mahdy, Rasha, Shaker, Mohamed E.
Format: Article
Language:English
Subjects:
Aged
Aqueous Humor - metabolism
Aqueous humour
Biomarkers - metabolism
Cytokines
Diabetes
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - metabolism
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Fluorescein Angiography - methods
Hemoglobin
Humans
Interleukins
Interleukins - metabolism
Lipids
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Original Paper
Pathogenesis
Retina
Retina - pathology
Retrospective Studies
Risk analysis
Slit Lamp Microscopy
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Summary:Purpose Interleukin (IL)-27 has been reported to possess anti- and proinflammatory properties in several immune related-disorders, but its role in diabetic retinopathy is still elusive. Here, we aimed to (i) evaluate IL-27 concentrations in serum and aqueous humor of diabetic patients with or without retinopathy and (ii) test whether IL-27 is correlated with some risk factors of diabetic retinopathy. Methods The study comprised 60 diabetic patients with and without retinopathy along with 20 healthy controls. Serum and aqueous humor concentrations of IL-27 were assessed by ELISA. Results The mean of IL-27 concentration in aqueous humor in patients with diabetic retinopathy (6.7 ± 2.7 ng/L) was significantly elevated in comparison with either diabetic patients without retinopathy (4.6 ± 0.5 ng/L) or healthy control group (4.1 ± 0.8 ng/L). Besides, IL-27 concentration in aqueous humor was positively correlated with serum glucose, lipid profile and glycated hemoglobin (HbA1c). Conclusions Based on this study, IL-27 is implicated in the pathogenesis of diabetic retinopathy and positively correlates with the disorder progression.
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-017-0655-7