Sulfonated chitosan-encapsulated HAp@Fe3O4: an efficient and recyclable magnetic nanocatalyst for rapid eco-friendly synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4, 5]imidazo[1,2-a]pyrimidine-3-carbonitriles

A one-pot, multi-component, synthetic method for preparation of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles has been developed. It was accomplished by mixing 2-aminobenzimidazole, aldehyde and malononitrile in the presence of S-Chit-HAp@Fe 3 O 4 as a nanocatal...

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Bibliographic Details
Published in:Research on chemical intermediates 2018-10, Vol.44 (10), p.5801-5815
Main Authors: Mahire, Vilas N., Patil, Girish P., Deore, Amol B., Chavan, Padmakar G., Jirimali, Harishchandra D., Mahulikar, Pramod P.
Format: Article
Language:English
Subjects:
Aldehydes
Aminobenzimidazole
Aqueous solutions
Catalysis
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chitosan
Inorganic Chemistry
Iron oxides
Magnetic properties
Malononitrile
Nanoparticles
Physical Chemistry
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Summary:A one-pot, multi-component, synthetic method for preparation of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles has been developed. It was accomplished by mixing 2-aminobenzimidazole, aldehyde and malononitrile in the presence of S-Chit-HAp@Fe 3 O 4 as a nanocatalyst in aqueous medium. The catalyst (S-Chit-HAp@Fe 3 O 4 ) was synthesized using a co-precipitation method and further characterized by using FT-IR, XRD, FE-SEM, EDX, HR-TEM, TGA and VSM analysis. It was found that the catalyst exhibits magnetic properties and showed high catalytical activity for the synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles. Graphical Abstract S-Chit-HAp@Fe 3 O 4 nanoparticles catalyzing one-pot, multi-component synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles in aqueous medium has been reported herein.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-018-3456-3