Long-term enhancement of maze learning in mice via a generalized Mozart effect

Objectives: An animal model of the 'generalized Mozart effect' (GME) - enhanced/normalized higher brain function in response to music exposure - has been established. We extend those results in two studies using another species (mice). Study 1: (1) maze testing after music exposure was ext...

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Bibliographic Details
Published in:Neurological research (New York) 2005-12, Vol.27 (8), p.791-796
Main Authors: Aoun, Peter, Jones, Timothy, Shaw, Gordon L., Bodner, Mark
Format: Article
Language:English
Subjects:
Animals
Cerebral Cortex - physiology
CORTICAL COLUMN
EEG
EPILEPSY
FMRI
Higher Nervous Activity - physiology
Humans
Mammals - physiology
Maze Learning - physiology
Mice - physiology
Music
Rats - physiology
Species Specificity
Time Factors
TRION MODEL OF CORTEX
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Summary:Objectives: An animal model of the 'generalized Mozart effect' (GME) - enhanced/normalized higher brain function in response to music exposure - has been established. We extend those results in two studies using another species (mice). Study 1: (1) maze testing after music exposure was extended to a minimum of 6 hours; (2) no exposure to music in utero. Study 2: (1) music exposure time further reduced; (2) maze testing extended to 24 hours. Methods: Study 1: two mouse groups were exposed to music continuously for 10 hours per day for 10 weeks (Group I: Mozart's Sonata K.448, Group II: Beethoven's Fur Elise). After 10 weeks, the ability to negotiate a T-maze was assessed (recording working time in maze, number of errors). Maze ability was tested 6 hours following the last music exposure. Study 2: two mouse groups were exposed periodically to music (58% silence) 10 hours per day for 10 weeks. Experiments after 10 weeks examined the groups' abilities to run the maze (recording working time/errors). Experiments were conducted 24 hours following the last music exposure. Results: The Mozart group exhibited significant enhancements compared with the control mice in both studies, i.e. significantly lower working time (p
ISSN:0161-6412
1743-1328
DOI:10.1179/016164105X63647