Bleomycin upregulates expression of γ-glutamylcysteine synthetase in pulmonary artery endothelial cells

The chemotherapeutic agent bleomycin induced pulmonary fibrosis through the generation of reactive oxygen species (ROS), which are thought to contribute to cellular damage and pulmonary injury. Day et al hypothesized that bleomycin activates oxidative stress response pathways and regulates cellular...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2002-06, Vol.26 (6), p.L1349-L1357
Main Authors: DAY, Regina M, SUZUKI, Yuichiro J, LUM, Julie M, WHITE, Alexander C, FANBURG, Barry L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cellular biology
Drug toxicity and drugs side effects treatment
Medical sciences
Oxygen
Pharmacology. Drug treatments
Proteins
Toxicity: respiratory system, ent, stomatology
Online Access:Get full text
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Summary:The chemotherapeutic agent bleomycin induced pulmonary fibrosis through the generation of reactive oxygen species (ROS), which are thought to contribute to cellular damage and pulmonary injury. Day et al hypothesized that bleomycin activates oxidative stress response pathways and regulates cellular glutathione (GSH).
ISSN:1040-0605
1522-1504