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Effect of pterostilbene complexed with cyclodextrin on rat liver: potential reduction of oxidative damage and modulation redox-sensitive proteins
The objectives of this study were to promote the aqueous solubility of pterostilbene (PTS) by complexation with hydroxypropyl-β-cyclodextrin (HPβCD), characterize the complex under physical aspects, to make its oral administration feasible in biological tests, and to investigate their pharmacologica...
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Published in: | Medicinal chemistry research 2018-10, Vol.27 (10), p.2265-2278 |
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creator | Lacerda, Denise S. Bianchi, Sara E. Pinós, Wesley L. Campos-Carraro, Cristina Türck, Patrick Hickmann, Alexandre R. Pittol, Vanessa Teixeira, Rayane B. Belló-Klein, Adriane Bassani, Valquiria L. Araujo, Alex S. R. |
description | The objectives of this study were to promote the aqueous solubility of pterostilbene (PTS) by complexation with hydroxypropyl-β-cyclodextrin (HPβCD), characterize the complex under physical aspects, to make its oral administration feasible in biological tests, and to investigate their pharmacological properties. For 14 days, rats received daily PTS:HPΒCD complex at doses of 25, 50, or 100 mg kg
−1
per day orally. The results showed no kidney or liver damage, nor any induction of apoptosis by the administered doses. Also, the complex showed dose-dependent antioxidant effects in the rat liver, as evidenced by a reduction in lipid peroxidation and reactive oxygen species, as well as an increase in non-enzymatic antioxidant. PTS:HPΒCD complex also increased the expression of sensitive redox proteins such as AKT and GSK-3β related to the insulin signaling pathway in the liver. Thus, the complexation demonstrated to be able to increase the apparent solubility of PTS making feasible dose curve administration and could be a food alternative complementary to antioxidant therapeutic. Therefore, the PTS:HPβCD complex can be used for prevention of diseases related to oxidative damage and insulin signaling. |
doi_str_mv | 10.1007/s00044-018-2233-6 |
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−1
per day orally. The results showed no kidney or liver damage, nor any induction of apoptosis by the administered doses. Also, the complex showed dose-dependent antioxidant effects in the rat liver, as evidenced by a reduction in lipid peroxidation and reactive oxygen species, as well as an increase in non-enzymatic antioxidant. PTS:HPΒCD complex also increased the expression of sensitive redox proteins such as AKT and GSK-3β related to the insulin signaling pathway in the liver. Thus, the complexation demonstrated to be able to increase the apparent solubility of PTS making feasible dose curve administration and could be a food alternative complementary to antioxidant therapeutic. Therefore, the PTS:HPβCD complex can be used for prevention of diseases related to oxidative damage and insulin signaling.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-018-2233-6</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>AKT protein ; Antioxidants ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Complexation ; Cyclodextrins ; Insulin ; Kidneys ; Lipid peroxidation ; Liver ; Oral administration ; Original Research ; Pharmacology ; Pharmacology/Toxicology ; Proteins ; Reactive oxygen species ; Reduction ; Rodents ; Signal transduction ; Signaling ; Solubility ; β-Cyclodextrin</subject><ispartof>Medicinal chemistry research, 2018-10, Vol.27 (10), p.2265-2278</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-e02940a2d113bfbb47e5c2b7ebb52c3845256809a7c14a4430c76d64b8e0d7523</citedby><cites>FETCH-LOGICAL-c316t-e02940a2d113bfbb47e5c2b7ebb52c3845256809a7c14a4430c76d64b8e0d7523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Lacerda, Denise S.</creatorcontrib><creatorcontrib>Bianchi, Sara E.</creatorcontrib><creatorcontrib>Pinós, Wesley L.</creatorcontrib><creatorcontrib>Campos-Carraro, Cristina</creatorcontrib><creatorcontrib>Türck, Patrick</creatorcontrib><creatorcontrib>Hickmann, Alexandre R.</creatorcontrib><creatorcontrib>Pittol, Vanessa</creatorcontrib><creatorcontrib>Teixeira, Rayane B.</creatorcontrib><creatorcontrib>Belló-Klein, Adriane</creatorcontrib><creatorcontrib>Bassani, Valquiria L.</creatorcontrib><creatorcontrib>Araujo, Alex S. R.</creatorcontrib><title>Effect of pterostilbene complexed with cyclodextrin on rat liver: potential reduction of oxidative damage and modulation redox-sensitive proteins</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>The objectives of this study were to promote the aqueous solubility of pterostilbene (PTS) by complexation with hydroxypropyl-β-cyclodextrin (HPβCD), characterize the complex under physical aspects, to make its oral administration feasible in biological tests, and to investigate their pharmacological properties. For 14 days, rats received daily PTS:HPΒCD complex at doses of 25, 50, or 100 mg kg
−1
per day orally. The results showed no kidney or liver damage, nor any induction of apoptosis by the administered doses. Also, the complex showed dose-dependent antioxidant effects in the rat liver, as evidenced by a reduction in lipid peroxidation and reactive oxygen species, as well as an increase in non-enzymatic antioxidant. PTS:HPΒCD complex also increased the expression of sensitive redox proteins such as AKT and GSK-3β related to the insulin signaling pathway in the liver. Thus, the complexation demonstrated to be able to increase the apparent solubility of PTS making feasible dose curve administration and could be a food alternative complementary to antioxidant therapeutic. Therefore, the PTS:HPβCD complex can be used for prevention of diseases related to oxidative damage and insulin signaling.</description><subject>AKT protein</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Complexation</subject><subject>Cyclodextrins</subject><subject>Insulin</subject><subject>Kidneys</subject><subject>Lipid peroxidation</subject><subject>Liver</subject><subject>Oral administration</subject><subject>Original Research</subject><subject>Pharmacology</subject><subject>Pharmacology/Toxicology</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Reduction</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Solubility</subject><subject>β-Cyclodextrin</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKBDEQRRtRcBz9AHcB162VRz_Gncj4gAE3ug7ppHqM9CRtktH2M_xjoyO4clUFde4tOEVxSuGcAjQXEQCEKIG2JWOcl_VeMaNVJcqWMtjPO-SdVYwfFkcxvgDwBkQ1Kz6XfY86Ed-TMWHwMdmhQ4dE-8044ISGvNv0TPSHHrzBKQXriHckqEQG-4bhkow-oUtWDSSg2epk8znX-ckalTJCjNqoNRLlDNl4sx3UD5JhP5URXbQ_1Bhyj3XxuDjo1RDx5HfOi6eb5eP1Xbl6uL2_vlqVmtM6lQhsIUAxQynv-q4TDVaadQ12XcU0b0XFqrqFhWo0FUoIDrqpTS26FsE0WcS8ONv15sevW4xJvvhtcPmlZBTatuWUQqbojtLZTQzYyzHYjQofkoL8Ni935mU2L7_Nyzpn2C4TM-vWGP6a_w99AXabiWg</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Lacerda, Denise S.</creator><creator>Bianchi, Sara E.</creator><creator>Pinós, Wesley L.</creator><creator>Campos-Carraro, Cristina</creator><creator>Türck, Patrick</creator><creator>Hickmann, Alexandre R.</creator><creator>Pittol, Vanessa</creator><creator>Teixeira, Rayane B.</creator><creator>Belló-Klein, Adriane</creator><creator>Bassani, Valquiria L.</creator><creator>Araujo, Alex S. R.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20181001</creationdate><title>Effect of pterostilbene complexed with cyclodextrin on rat liver: potential reduction of oxidative damage and modulation redox-sensitive proteins</title><author>Lacerda, Denise S. ; Bianchi, Sara E. ; Pinós, Wesley L. ; Campos-Carraro, Cristina ; Türck, Patrick ; Hickmann, Alexandre R. ; Pittol, Vanessa ; Teixeira, Rayane B. ; Belló-Klein, Adriane ; Bassani, Valquiria L. ; Araujo, Alex S. 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R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of pterostilbene complexed with cyclodextrin on rat liver: potential reduction of oxidative damage and modulation redox-sensitive proteins</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2018-10-01</date><risdate>2018</risdate><volume>27</volume><issue>10</issue><spage>2265</spage><epage>2278</epage><pages>2265-2278</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>The objectives of this study were to promote the aqueous solubility of pterostilbene (PTS) by complexation with hydroxypropyl-β-cyclodextrin (HPβCD), characterize the complex under physical aspects, to make its oral administration feasible in biological tests, and to investigate their pharmacological properties. For 14 days, rats received daily PTS:HPΒCD complex at doses of 25, 50, or 100 mg kg
−1
per day orally. The results showed no kidney or liver damage, nor any induction of apoptosis by the administered doses. Also, the complex showed dose-dependent antioxidant effects in the rat liver, as evidenced by a reduction in lipid peroxidation and reactive oxygen species, as well as an increase in non-enzymatic antioxidant. PTS:HPΒCD complex also increased the expression of sensitive redox proteins such as AKT and GSK-3β related to the insulin signaling pathway in the liver. Thus, the complexation demonstrated to be able to increase the apparent solubility of PTS making feasible dose curve administration and could be a food alternative complementary to antioxidant therapeutic. Therefore, the PTS:HPβCD complex can be used for prevention of diseases related to oxidative damage and insulin signaling.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-018-2233-6</doi><tpages>14</tpages></addata></record> |
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subjects | AKT protein Antioxidants Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Complexation Cyclodextrins Insulin Kidneys Lipid peroxidation Liver Oral administration Original Research Pharmacology Pharmacology/Toxicology Proteins Reactive oxygen species Reduction Rodents Signal transduction Signaling Solubility β-Cyclodextrin |
title | Effect of pterostilbene complexed with cyclodextrin on rat liver: potential reduction of oxidative damage and modulation redox-sensitive proteins |
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