ERK activation and mitogenesis in human airway smooth muscle cells

Asthmatic airways are characterized by an increase in smooth muscle mass, due mainly to hyperplasia. Many studies suggest that extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2, respectively), one group of the mitogen-activated protein (MAP) kinase superfamily, play a key role in the sig...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2001-05, Vol.24 (5), p.L1019-L1029
Main Authors: LEE, Jin-Hee, JOHNSON, Peter R. A, ROTH, Michael, HUNT, Nicholas H, BLACK, Judith L
Format: Article
Language:English
Subjects:
Asthma
Biological and medical sciences
Cellular biology
Chronic obstructive pulmonary disease, asthma
Medical research
Medical sciences
Pneumology
Respiratory system
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Summary:Asthmatic airways are characterized by an increase in smooth muscle mass, due mainly to hyperplasia. Many studies suggest that extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2, respectively), one group of the mitogen-activated protein (MAP) kinase superfamily, play a key role in the signal transduction pathway leading to cell proliferation.
ISSN:1040-0605
1522-1504