ERK activation and mitogenesis in human airway smooth muscle cells

Asthmatic airways are characterized by an increase in smooth muscle mass, due mainly to hyperplasia. Many studies suggest that extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2, respectively), one group of the mitogen-activated protein (MAP) kinase superfamily, play a key role in the sig...

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Published in:American journal of physiology. Lung cellular and molecular physiology 2001-05, Vol.24 (5), p.L1019-L1029
Main Authors: LEE, Jin-Hee, JOHNSON, Peter R. A, ROTH, Michael, HUNT, Nicholas H, BLACK, Judith L
Format: Article
Language:English
Subjects:
Asthma
Biological and medical sciences
Cellular biology
Chronic obstructive pulmonary disease, asthma
Medical research
Medical sciences
Pneumology
Respiratory system
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container_end_page L1029
container_issue 5
container_start_page L1019
container_title American journal of physiology. Lung cellular and molecular physiology
container_volume 24
creator LEE, Jin-Hee
JOHNSON, Peter R. A
ROTH, Michael
HUNT, Nicholas H
BLACK, Judith L
description Asthmatic airways are characterized by an increase in smooth muscle mass, due mainly to hyperplasia. Many studies suggest that extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2, respectively), one group of the mitogen-activated protein (MAP) kinase superfamily, play a key role in the signal transduction pathway leading to cell proliferation.
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source American Physiological Society Free
subjects Asthma
Biological and medical sciences
Cellular biology
Chronic obstructive pulmonary disease, asthma
Medical research
Medical sciences
Pneumology
Respiratory system
title ERK activation and mitogenesis in human airway smooth muscle cells
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