Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cells

Apoptosis may be important in the exacerbation of endothelial cell injury or limitation of endothelial cell proliferation. We have found that extracellular ATP (exATP) and adenosine cause endothelial apoptosis and that the development of apoptosis is linked to intracellular metabolism of adenosine A...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1998-08, Vol.19 (2), p.L379-L388
Main Authors: ROUNDS, S, WINNIE LIN YEE, DAWICKI, D. D, HARRINGTON, E, PARKS, N, CUTAIA, M. V
Format: Article
Language:English
Subjects:
Ageing, cell death
Biological and medical sciences
Blood vessels
Cell physiology
Cells
Cellular biology
Enzymes
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Proteins
Respiratory system
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Summary:Apoptosis may be important in the exacerbation of endothelial cell injury or limitation of endothelial cell proliferation. We have found that extracellular ATP (exATP) and adenosine cause endothelial apoptosis and that the development of apoptosis is linked to intracellular metabolism of adenosine ADawicki, D. D.,D. Chatterjee, J. Wyche, and S. Rounds. Am. J. Physiol. 273 (Lung Cell Mol. Physiol. 17): L485-L494, 19971.
ISSN:1040-0605
1522-1504