Sulfation of extracellular matrices modifies growth factor effects on type II cells on laminin substrata

The alveolar basement membrane contains a variety of extracellular matrix (ECM) molecules, including laminin and sulfated glycosaminoglycans of proteoglycans. These mixtures exist within microdomains of differing levels of sulfate, which may specifically interact to be key determinants of the known...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1998-10, Vol.19 (4), p.L701-L708
Main Authors: SANNES, P. L, KHOSLA, J, LI, C.-M, PAGAN, I
Format: Article
Language:English
Subjects:
Air breathing
Biological and medical sciences
Cells
Fundamental and applied biological sciences. Psychology
Membranes
Physical growth
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
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Summary:The alveolar basement membrane contains a variety of extracellular matrix (ECM) molecules, including laminin and sulfated glycosaminoglycans of proteoglycans. These mixtures exist within microdomains of differing levels of sulfate, which may specifically interact to be key determinants of the known capacity of the type II cell to respond to certain growth factors.
ISSN:1040-0605
1522-1504