Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition

Elevation in cell cAMP content can inhibit mitogenic signaling in cultured human airway smooth muscle (HASM) cells. We studied the effects of the type-3-selective phosphodiesterase inhibitor siguazodan, the type-4-selective phosphodiesterase inhibitor rolipram, and the nonselective inhibitor 3-isobu...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1999-03, Vol.20 (3), p.L412-L419
Main Authors: BILLINGTON, C. K, JOSEPH, S. K, SWAN, C, SCOTT, M. G. H, JOBSON, T. M, HALL, I. P
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cell cycle, cell proliferation
Cell physiology
Fundamental and applied biological sciences. Psychology
Lungs
Molecular and cellular biology
Respiratory system
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Summary:Elevation in cell cAMP content can inhibit mitogenic signaling in cultured human airway smooth muscle (HASM) cells. We studied the effects of the type-3-selective phosphodiesterase inhibitor siguazodan, the type-4-selective phosphodiesterase inhibitor rolipram, and the nonselective inhibitor 3-isobutyl-1-methylxanthine (IBMX) on proliferation of cultured HASM cells.
ISSN:1040-0605
1522-1504