Hypoxic exposure time dependently modulates endothelin- induced contraction of pulmonary artery smooth muscle

Endothelins (ETs) have been implicated in the pathogenesis of hypoxia-induced pulmonary hypertension. We determined whether hypoxic exposure of rats (10% O2-90% N2, 1 atm, 1-48 days) altered contraction to ET in isolated segments of endothelium-denuded extralobar branch pulmonary artery (PA) and aor...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1998-04, Vol.18 (4), p.L552-L559
Main Authors: BIALECKI, R. A, FISHER, C. S, MURDOCH, W. W, BARTHLOW, H. G, STOW, R. B, MALLAMACI, M, RUMSEY, W
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood vessels
Cell physiology
Effects of physical and chemical agents
Fundamental and applied biological sciences. Psychology
Hypertension
Lungs
Molecular and cellular biology
Muscular system
Rodents
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Summary:Endothelins (ETs) have been implicated in the pathogenesis of hypoxia-induced pulmonary hypertension. We determined whether hypoxic exposure of rats (10% O2-90% N2, 1 atm, 1-48 days) altered contraction to ET in isolated segments of endothelium-denuded extralobar branch pulmonary artery (PA) and aorta. Hypoxic exposure increased hematocrit, right ventricular hypertrophy, and ET-1 plasma concentration.
ISSN:1040-0605
1522-1504