Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells

The effects of 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, on the human bronchial epithelial cell line BEAS-2B, were examined. Mitogen-activated protein kinases (MAPKs) may mediate signal transduction pathways induced by peroxynitrite in lung epithelial cells leading to cell death.

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2003-06, Vol.28 (6), p.L1112-L1120
Main Authors: NABEYRAT, Elodie, JONES, Gina E, FENWICK, Peter S, BARNES, Peter J, DONNELLY, Louise E
Format: Article
Language:English
Subjects:
Air breathing
Biological and medical sciences
Cells
Enzymes
Fundamental and applied biological sciences. Psychology
Lungs
Nitric oxide
Proteins
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
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Summary:The effects of 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, on the human bronchial epithelial cell line BEAS-2B, were examined. Mitogen-activated protein kinases (MAPKs) may mediate signal transduction pathways induced by peroxynitrite in lung epithelial cells leading to cell death.
ISSN:1040-0605
1522-1504