Ion exchange activity in pulmonary artery smooth muscle cells : the response to hypoxia

The purposes of this study were to determine 1) the presence of the major ion transport activities that regulate cytoplasmic pH (pHc) in cat pulmonary artery smooth muscle cells, i.e., Na+/H+ and the Na+-dependent and -independent Cl-/HCO-3 exchange, 2) whether pHc changes in cells from small (SPAs)...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2001-02, Vol.24 (2), p.L264-L271
Main Authors: MADDEN, Jane A, RAY, Daniel E, KELLER, Peter A, KLEINMAN, Jack G
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Blood vessels
Cats
Cells
Ions
Lungs
Medical sciences
Pneumology
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Sodium
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Summary:The purposes of this study were to determine 1) the presence of the major ion transport activities that regulate cytoplasmic pH (pHc) in cat pulmonary artery smooth muscle cells, i.e., Na+/H+ and the Na+-dependent and -independent Cl-/HCO-3 exchange, 2) whether pHc changes in cells from small (SPAs) and large (LPAs) pulmonary arteries during hypoxia, and 3) whether changes in pHc are due to changes in the balance of exchange activities.
ISSN:1040-0605
1522-1504