Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions

We reported previously that mast cell tryptase is a growth factor for dog tracheal smooth muscle cells. The goals of our current experiments were to determine if tryptase also is mitogenic in cultured human airway smooth muscle cells, to compare its strength as a growth factor with that of other mit...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2002-02, Vol.26 (2), p.L197-L206
Main Authors: BROWN, James K, JONES, Cary A, ROONEY, Leeann A, CAUGHEY, George H, HALL, Ian P
Format: Article
Language:English
Subjects:
Air breathing
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Infections
Lungs
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
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Summary:We reported previously that mast cell tryptase is a growth factor for dog tracheal smooth muscle cells. The goals of our current experiments were to determine if tryptase also is mitogenic in cultured human airway smooth muscle cells, to compare its strength as a growth factor with that of other mitogenic serine proteases, and to determine whether its proteolytic actions are required for mitogenesis.
ISSN:1040-0605
1522-1504