IL-12 overexpression in mice as a model for Sjögren lung disease

Interleukin-12 (IL- 12), a Th1 proinflammatory cytokine, is reported to be increased in Sjogren syndrome. To evaluate the effects of local Th1/Th2 deregulation, we generated a transgenic mouse model that overexpresses IL-12 in the lungs. IL-12 transgenic mice developed bronchial and alveolar abnorma...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2006-10, Vol.291 (4), p.69
Main Authors: McGrath-Morrow, Sharon, Laube, Beth, Shey-Cherng Tzou, Cho, Cecilia
Format: Article
Language:English
Subjects:
Cells
Cytokines
Lungs
Respiratory diseases
Rodents
Transgenic animals
Online Access:Get full text
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Summary:Interleukin-12 (IL- 12), a Th1 proinflammatory cytokine, is reported to be increased in Sjogren syndrome. To evaluate the effects of local Th1/Th2 deregulation, we generated a transgenic mouse model that overexpresses IL-12 in the lungs. IL-12 transgenic mice developed bronchial and alveolar abnormalities strikingly similar to those found in the lungs of Sjogren patients. Pathologically, lung abnormalities began at ~4 mo of age and were characterized by lymphocytic infiltrates around the bronchi, intraluminal periodic acid Schiff-positive debris, increased cell proliferation in the alveolar region, and increased interstitial and alveolar macrophages. Functionally, these abnormalities translated into decreased mucociliary clearance (P
ISSN:1040-0605
1522-1504