TNF-α disruption of lung endothelial integrity: reduced integrin mediated adhesion to fibronectin

Tumor necrosis factor-alpha (TNF-alpha) causes an increase in transendothelial protein permeability of confluent monolayers of calf pulmonary artery endothelial (CPAE) cells, and the addition of plasma fibronectin (pFn) to the culture medium can attenuate this increase in permeability. We determined...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2002-02, Vol.26 (2), p.L316-L329
Main Authors: ROTUNDO, Robert F, CURTIS, Theresa M, SHAH, Melissa D, BAOCHONG GAO, MASTRANGELO, Anthony, LAFLAMME, Susan E, SABA, Thomas M
Format: Article
Language:English
Subjects:
Air breathing
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Lungs
Permeability
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor necrosis factor-alpha (TNF-alpha) causes an increase in transendothelial protein permeability of confluent monolayers of calf pulmonary artery endothelial (CPAE) cells, and the addition of plasma fibronectin (pFn) to the culture medium can attenuate this increase in permeability. We determined if reduced integrin function had a role in decreased endothelial cell adhesion to immobilized Fn after exposure of the endothelial monolayers to TNF-alpha.
ISSN:1040-0605
1522-1504