Surface activity of a synthetic lung surfactant containing a phospholipase-resistant phosphonolipid analog of dipalmitoyl phosphatidycholine

Surface activity and sensitivity to inhibition from phospholipase A2 (PLA2), lysophosphatidylcholine (LPC), and serum albumin were studied for a synthetic C16:0 diether phosphonolipid (DEPN-8) combined with 1.5% by weight of mixed hydrophobic surfactant proteins (SP)-B/C purified from calf lung surf...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2003-09, Vol.29 (3), p.L550
Main Authors: Wang, Z, Schwan, A L, Lairson, L L, O'Donnell, J S
Format: Article
Language:English
Subjects:
Lipids
Lungs
Proteins
Surfactants
Online Access:Get full text
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Summary:Surface activity and sensitivity to inhibition from phospholipase A2 (PLA2), lysophosphatidylcholine (LPC), and serum albumin were studied for a synthetic C16:0 diether phosphonolipid (DEPN-8) combined with 1.5% by weight of mixed hydrophobic surfactant proteins (SP)-B/C purified from calf lung surfactant extract (CLSE). Pure DEPN-8 had better adsorption and film respreading than the major lung surfactant phospholipid dipalmitoyl phosphatidylcholine and reached minimum surface tensions
ISSN:1040-0605
1522-1504